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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Kuerban, Subinuer Chen, Hangyu Chen, Long Zhang, Lei Li, Xuehui Zhen, Baixin Xiao, Hong Chen, Yingzhu Zhou, Haitao Liang, Zhen Xu, Guobing Tao, Yicun Lin, Jian Kang, Xiaozheng |
| Abstract | Background A blood-based approach to monitor metastasis and recurrence of esophageal squamous cell carcinoma (ESCC) remains undeveloped. This study aimed to establish a dependable model utilizing cfDNA 5-hydroxymethylcytosines (5hmC) signatures to detect these conditions in ESCC. Methods The 5hmC-Seal technique was employed to generate comprehensive 5hmC profiles from the plasma cell-free DNA (cfDNA) of 122 ESCC patients, classified into 72 with metastasis, 50 without metastasis, 30 with recurrence, and 92 without recurrence. Initial steps involved identifying distinct hydroxymethylation signatures linked to metastasis and recurrence. Machine learning algorithms were then utilized to construct predictive models. Results The study confirmed that 5hmC-based markers are predictive of metastasis and recurrence among ESCC patients. The analysis of 14 5hmC biomarkers revealed a sensitivity of 88.90% and a specificity of 84.00% (AUC = 0.922) in differentiating patients with ESCC metastasis from those without in the validation cohort. Similarly, 11 5hmC biomarkers showed a sensitivity of 93.30% and a specificity of 89.10% (AUC = 0.936) in identifying recurrent versus non-recurrent ESCC cases. Additionally, a wp-score for metastasis and recurrence, derived from the 5hmC marker, prognosticated patient outcomes. Conclusions The findings indicate that 5hmC markers from cfDNA serve as effective epigenetic indicators for the non-invasive detection of ESCC metastasis and recurrence. |
| Related Links | https://wjso.biomedcentral.com/counter/pdf/10.1186/s12957-025-03747-9.pdf |
| Ending Page | 17 |
| Page Count | 17 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14777819 |
| DOI | 10.1186/s12957-025-03747-9 |
| Journal | World Journal of Surgical Oncology |
| Issue Number | 1 |
| Volume Number | 23 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2025-03-15 |
| Access Restriction | Open |
| Subject Keyword | Surgical Oncology 5-hydroxymethylcytosine Esophageal squamous cell carcinoma Liquid biopsy Metastasis Recurrence |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology Surgery |
| Journal Impact Factor | 2.5/2023 |
| 5-Year Journal Impact Factor | 2.8/2023 |
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