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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Xin, Shaowei Wen, Miaomiao Tian, Yahui Dong, Honghong Wan, Zitong Jiang, Suxin Meng, Fancheng Xiong, Yanlu Han, Yong |
| Abstract | Lung adenocarcinoma is the most prevalent type of lung cancer, with invasive lung adenocarcinoma being the most common subtype. Screening and early treatment of high-risk individuals have improved survival; however, significant differences in prognosis still exist among patients at the same stage, especially in the early stages. Invasive lung adenocarcinoma has different histological morphologies and biological characteristics that can distinguish its prognosis. Notably, several studies have found that the pathological subtypes of invasive lung adenocarcinoma are closely associated with clinical treatment. This review summarised the distribution of various pathological subtypes of invasive lung adenocarcinoma in the population and their relationship with sex, smoking, imaging features, and other histological characteristics. We comprehensively analysed the genetic characteristics and biomarkers of the different pathological subtypes of invasive lung adenocarcinoma. Understanding the interaction between the pathological subtypes of invasive lung adenocarcinoma and the tumour microenvironment helps to reveal new therapeutic targets for lung adenocarcinoma. We also extensively reviewed the prognosis of various pathological subtypes and their effects on selecting surgical methods and adjuvant therapy and explored future treatment strategies. |
| Related Links | https://wjso.biomedcentral.com/counter/pdf/10.1186/s12957-025-03701-9.pdf |
| Ending Page | 19 |
| Page Count | 19 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14777819 |
| DOI | 10.1186/s12957-025-03701-9 |
| Journal | World Journal of Surgical Oncology |
| Issue Number | 1 |
| Volume Number | 23 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2025-02-27 |
| Access Restriction | Open |
| Subject Keyword | Surgical Oncology Tumour microenvironment Lung adenocarcinoma Subtype Histological Pathology |
| Content Type | Text |
| Resource Type | Review |
| Subject | Oncology Surgery |
| Journal Impact Factor | 2.5/2023 |
| 5-Year Journal Impact Factor | 2.8/2023 |
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