NDLI: Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study

Content Provider	Springer Nature : BioMed Central
Author	Merritt, Melissa A. Riboli, Elio Murphy, Neil Kadi, Mai Tjønneland, Anne Olsen, Anja Overvad, Kim Dossus, Laure Dartois, Laureen Clavel-Chapelon, Françoise Fortner, Renée T. Katzke, Verena A. Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico Sieri, Sabina Tumino, Rosario Sacerdote, Carlotta Panico, Salvatore Bueno-de-Mesquita, H. Bas Peeters, Petra H. Lund, Eiliv Nakamura, Aurelie Weiderpass, Elisabete Quirós, J. Ramón Agudo, Antonio Molina-Montes, Esther Larrañaga, Nerea Dorronsoro, Miren Cirera, Lluís Barricarte, Aurelio Olsson, Åsa Butt, Salma Idahl, Annika Lundin, Eva Wareham, Nicholas J. Key, Timothy J. Brennan, Paul Ferrari, Pietro Wark, Petra A. Norat, Teresa Cross, Amanda J. Gunter, Marc J.
Abstract	Background Reproductive events are associated with important physiologic changes, yet little is known about how reproductive factors influence long-term health in women. Our objective was to assess the relation of reproductive characteristics with all-cause and cause-specific mortality risk. Methods The analysis was performed within the European Investigation into Cancer and Nutrition prospective cohort study, which enrolled >500,000 women and men from 1992 to 2000, who were residing in a given town/geographic area in 10 European countries. The current analysis included 322,972 eligible women aged 25–70 years with 99 % complete follow-up for vital status. We assessed reproductive characteristics reported at the study baseline including parity, age at the first birth, breastfeeding, infertility, oral contraceptive use, age at menarche and menopause, total ovulatory years, and history of oophorectomy/hysterectomy. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for mortality were determined using Cox proportional hazards regression models adjusted for menopausal status, body mass index, physical activity, education level, and smoking status/intensity and duration. Results During a mean follow-up of 12.9 years, 14,383 deaths occurred. The HR (95 % CI) for risk of all-cause mortality was lower in parous versus nulliparous women (0.80; 0.76–0.84), in women who had ever versus never breastfed (0.92; 0.87–0.97), in ever versus never users of oral contraceptives (among non-smokers; 0.90; 0.86–0.95), and in women reporting a later age at menarche (≥15 years versus <12; 0.90; 0.85–0.96; P for trend = 0.038). Conclusions Childbirth, breastfeeding, oral contraceptive use, and a later age at menarche were associated with better health outcomes. These findings may contribute to the development of improved strategies to promote better long-term health in women.
Related Links	https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-015-0484-3.pdf
Ending Page	15
Page Count	15
Starting Page	1
File Format	HTM / HTML
ISSN	17417015
DOI	10.1186/s12916-015-0484-3
Journal	BMC Medicine
Issue Number	1
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2015-10-30
Access Restriction	Open
Subject Keyword	Medicine Public Health Biomedicine Age at menarche Age at menopause Breastfeeding Mortality Oral contraceptives Parity Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Medicine
Journal Impact Factor	7.1/2023
5-Year Journal Impact Factor	8.8/2023

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