NDLI: Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study

Content Provider	Springer Nature : BioMed Central
Author	Etemadi, Arash Kamangar, Farin Islami, Farhad Poustchi, Hossein Pourshams, Akram Brennan, Paul Boffetta, Paolo Malekzadeh, Reza Dawsey, Sanford M Abnet, Christian C Emadi, Ashkan
Abstract	Background A few studies have shown an association between blood group alleles and vascular disease, including atherosclerosis, which is thought to be due to the higher level of von Willebrand factor in these individuals and the association of blood group locus variants with plasma lipid levels. No large population-based study has explored this association with overall and cause-specific mortality. Methods We aimed to study the association between ABO blood groups and overall and cause-specific mortality in the Golestan Cohort Study. In this cohort, 50,045 people 40- to 70-years old were recruited between 2004 and 2008, and followed annually to capture all incident cancers and deaths due to any cause. We used Cox regression models adjusted for age, sex, smoking, socioeconomic status, ethnicity, place of residence, education and opium use. Results During a total of 346,708 person-years of follow-up (mean duration 6.9 years), 3,623 cohort participants died. Non-O blood groups were associated with significantly increased total mortality (hazard ratio (HR) = 1.09; 95% confidence interval (CI): 1.01 to 1.17) and cardiovascular disease mortality (HR = 1.15; 95% CI: 1.03 to 1.27). Blood group was not significantly associated with overall cancer mortality, but people with group A, group B, and all non-O blood groups combined had increased risk of incident gastric cancer. In a subgroup of cohort participants, we also showed higher plasma total cholesterol and low-density lipoprotein (LDL) in those with blood group A. Conclusions Non-O blood groups have an increased mortality, particularly due to cardiovascular diseases, which may be due to the effect of blood group alleles on blood biochemistry or their effect on von Willebrand factor and factor VIII levels. Please see related commentary http://dx.doi.org/10.1186/s12916-014-0250-y .
Related Links	https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-014-0237-8.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
ISSN	17417015
DOI	10.1186/s12916-014-0237-8
Journal	BMC Medicine
Issue Number	1
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2015-01-15
Access Restriction	Open
Subject Keyword	Medicine Public Health Biomedicine Blood group ABO Rh Mortality Cancer Cardiovascular disease Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Medicine
Journal Impact Factor	7.1/2023
5-Year Journal Impact Factor	8.8/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study

The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer

Retrospective study of frequency of ABO and Rhesus blood group among population of Safdarabad and Faisalabad cities of Pakistan

A phenome-wide association study of ABO blood groups

Evaluation of the frequency of ABO and Rh-Hr blood-group systems in different acquired cataracts type

High rhesus (Rh(D)) negative frequency and ethnic-group based ABO blood group distribution in Ethiopia

The blood microbiome and its association to cardiovascular disease mortality: case-cohort study

Cardiovascular disease in women with breast cancer – a nationwide cohort study

ABO / Rh-D Blood types and susceptibility to Corona Virus Disease-19 in Peshawar, Pakistan.

Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study

Similar Documents

Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study

The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer

Retrospective study of frequency of ABO and Rhesus blood group among population of Safdarabad and Faisalabad cities of Pakistan

A phenome-wide association study of ABO blood groups

Evaluation of the frequency of ABO and Rh-Hr blood-group systems in different acquired cataracts type

High rhesus (Rh(D)) negative frequency and ethnic-group based ABO blood group distribution in Ethiopia

The blood microbiome and its association to cardiovascular disease mortality: case-cohort study

Cardiovascular disease in women with breast cancer – a nationwide cohort study

ABO / Rh-D Blood types and susceptibility to Corona Virus Disease-19 in Peshawar, Pakistan.

Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study