NDLI: Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions

Content Provider	Springer Nature : BioMed Central
Author	Schmutzhard, Joachim Lackner, Peter Helbok, Raimund Hurth, Helene Verena Aregger, Fabian Cedric Muigg, Veronika Kegele, Josua Bunk, Sebastian Oberhammer, Lukas Fischer, Natalie Pinggera, Leyla Otieno, Allan Ogutu, Bernards Agbenyega, Tsiri Ansong, Daniel Adegnika, Ayola A. Issifou, Saadou Zorowka, Patrick Krishna, Sanjeev Mordmüller, Benjamin Schmutzhard, Erich Kremsner, Peter
Abstract	Background Severe malaria may influence inner ear function, although this possibility has not been examined prospectively. In a retrospective analysis, hearing impairment was found in 9 of 23 patients with cerebral malaria. An objective method to quickly evaluate the function of the inner ear are the otoacoustic emissions. Negative transient otoacoustic emissions are associated with a threshold shift of 20 dB and above. Methods This prospective multicenter study analyses otoacoustic emissions in patients with severe malaria up to the age of 10 years. In three study sites (Ghana, Gabon, Kenya) 144 patients with severe malaria and 108 control children were included. All malaria patients were treated with parental artesunate. Results In the control group, 92.6 % (n = 108, 95 % confidence interval 86.19–6.2 %) passed otoacoustic emission screening. In malaria patients, 58.5 % (n = 94, malaria vs controls p < 0.001, 95 % confidence interval 48.4–67.9 %) passed otoacoustic emission screening at the baseline measurement. The value increased to 65.2 % (n = 66, p < 0.001, 95 % confidence interval 53.1–75.5 %) at follow up 14–28 days after diagnosis of malaria. The study population was divided into severe non-cerebral malaria and severe malaria with neurological symptoms (cerebral malaria). Whereas otoacoustic emissions in severe malaria improved to a passing percentage of 72.9 % (n = 48, 95 % confidence interval 59–83.4 %) at follow-up, the patients with cerebral malaria showed a drop in the passing percentage to 33 % (n = 18) 3–7 days after diagnosis. This shows a significant impairment in the cerebral malaria group (p = 0.012 at days 3–7, 95 % confidence interval 16.3–56.3 %; p = 0.031 at day 14–28, 95 % confidence interval 24.5–66.3 %). Conclusion The presented data show that 40 % of children have involvement of the inner ear early in severe malaria. In children, audiological screening after severe malaria infection is not currently recommended, but is worth investigating in larger studies.
Related Links	https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-015-0366-8.pdf
Ending Page	8
Page Count	8
Starting Page	1
File Format	HTM / HTML
ISSN	17417015
DOI	10.1186/s12916-015-0366-8
Journal	BMC Medicine
Issue Number	1
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2015-05-28
Access Restriction	Open
Subject Keyword	Medicine Public Health Biomedicine Hearing impairment Otoacoustic emissions Severe malaria Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Medicine
Journal Impact Factor	7.1/2023
5-Year Journal Impact Factor	8.8/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Erratum to: Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study

Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study

Erratum to: Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study

A long-term follow-up study on otoacoustic emissions testing in paediatric patients with severe malaria in Gabon

Severe neurological sequelae and behaviour problems after cerebral malaria in Ugandan children

Hearing impairment after acute bacterial meningitis in children.

Otoacoustic emissions as a screening test for hearing impairment in children.

Murine malaria is associated with significant hearing impairment open access.

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study

Similar Documents

Erratum to: Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study

Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study

Erratum to: Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study

A long-term follow-up study on otoacoustic emissions testing in paediatric patients with severe malaria in Gabon

Severe neurological sequelae and behaviour problems after cerebral malaria in Ugandan children

Hearing impairment after acute bacterial meningitis in children.

Otoacoustic emissions as a screening test for hearing impairment in children.

Murine malaria is associated with significant hearing impairment open access.

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study