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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Livraghi, Luca Garber, Judy E. |
| Abstract | Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. Inhibition of PARPs is a promising strategy for targeting cancers with defective DNA-damage repair, including BRCA1 and BRCA2 mutation-associated breast and ovarian cancers. Several PARP inhibitors are currently in trials in the adjuvant, neoadjuvant, and metastatic settings for the treatment of ovarian, BRCA-mutated breast, and other cancers. We herein review the development of PARP inhibitors and the basis for the excitement surrounding these agents, their use as single agents and in combinations, as well as their toxicities, mechanisms of acquired resistance, and companion diagnostics. |
| Related Links | https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-015-0425-1.pdf |
| Ending Page | 16 |
| Page Count | 16 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17417015 |
| DOI | 10.1186/s12916-015-0425-1 |
| Journal | BMC Medicine |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2015-08-13 |
| Access Restriction | Open |
| Subject Keyword | Medicine Public Health Biomedicine BRCA Breast cancer PARP inhibitors Poly(ADP-ribose) polymerases Medicine/Public Health |
| Content Type | Text |
| Resource Type | Review |
| Subject | Medicine |
| Journal Impact Factor | 7.1/2023 |
| 5-Year Journal Impact Factor | 8.8/2023 |
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