NDLI: Effect of social influence on antiviral therapy behavior among chronic hepatitis B patients with different disease knowledge levels

Content Provider	Springer Nature : BioMed Central
Author	Deng, Qiwen Wu, Shiyin Liu, Wenbin
Abstract	Background Chronic hepatitis B (CHB) is a global health challenge with low rates of diagnosis and treatment worldwide. Since social factors and individual cognition significantly influence antiviral therapy adherence in CHB patients, both of which are shaped by patients’ understanding of hepatitis B, this study aimed to investigate the effects of social influences on antiviral therapy behavior among CHB patients with different levels of disease knowledge. Methods From March to October 2023, a survey was conducted among CHB patients in Fuqing City, Fujian Province. A self-designed scale was developed based on the attitude–social influence–efficacy (ASE) model, prototype willingness model (PWM), and theory of planned behavior (TPB). Using the mean score as the cutoff point, CHB patients were divided into high and low knowledge levels. Multi-group structural equation modeling (SEM) was used to validate the hypotheses and determine the mechanism of antiviral therapy behavior. Results A total of 611 individuals were ultimately included. Multi-group structural equation modeling (SEM) analyses revealed significant differences between patients with high and low disease knowledge levels across three pathways: social support towards self-efficacy (CR = -2.839, P < 0.05), social support towards attitude (CR = 2.142, P < 0.05), and self-efficacy towards behavior (CR = 3.720, P < 0.001). Social support had a stronger influence on self-efficacy in CHB patients with low disease knowledge compared to those with high disease knowledge. Among patients with higher disease knowledge, social support exerted a greater impact on treatment attitudes, while self-efficacy demonstrated a stronger influence on treatment behaviors. Conclusion To enhance the motivation and adherence of CHB patients to antiviral therapy, healthcare providers could implement tailored health education strategies based on patients’ varying levels of knowledge. Additionally, dynamic health goal-setting should be integrated to drive continuous health management. Furthermore, establishing a multi-tiered social support network that incorporates family involvement, community support groups, and healthcare institution collaboration is essential.
Related Links	https://bmcpublichealth.biomedcentral.com/counter/pdf/10.1186/s12889-025-22683-7.pdf
Ending Page	11
Page Count	11
Starting Page	1
File Format	HTM / HTML
ISSN	14712458
DOI	10.1186/s12889-025-22683-7
Journal	BMC Public Health
Issue Number	1
Volume Number	25
Language	English
Publisher	BioMed Central
Publisher Date	2025-04-17
Access Restriction	Open
Subject Keyword	Public Health Medicine Epidemiology Biostatistics Vaccine Environmental Health Social influence Chronic hepatitis B Antiviral therapy behavior Impact mechanism Multi-group structural equation modeling Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health
Journal Impact Factor	3.5/2023
5-Year Journal Impact Factor	3.9/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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