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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Hughes, William E. Spartano, Nicole L. Lefferts, Wesley K. Augustine, Jaqueline A. Heffernan, Kevin S. |
| Abstract | Background Sex differences in arterial stiffness and wave reflections may lead to disproportionate increases in afterload and myocardial work in women. We examined sex differences in arterial stiffness, pressure from wave reflections, measures of left ventricular (LV) energetics and myocardial work. Methods 99 Healthy adults participated in this study 84 were selected (42 females, 42 males) to be matched for potential confounders of central hemodynamic burden such as age, BMI, and mean arterial pressure. Aortic pressure waves were derived from the radial artery using a generalized transfer function. Pulse contour analysis and wave separation analysis were used to obtain: pulse wave velocity (PWV) as a measure of aortic stiffness, augmentation index (AIx) and reflection index (RIx) as measures of global wave reflections, LV pressure effort (∆Ew) as a measure of LV energy required to overcome wave reflections and the subendocardial viability ratio (SEVR) as a proxy of myocardial work. Results Women exhibited higher ∆Ew (p < 0.05), heart rate corrected AIx (p < 0.05) and RIx (p < 0.01), and lower PWV (p < 0.001) compared to men. Pressure from wave reflections (Pb) was significantly associated with ∆Ew in women (r = 0.81, p < 0.001), but not in men (r = 0.14, p > 0.05). There were no sex differences for SEVR (p = 0.4). Conclusion Women had higher pressure from wave reflections which was associated with greater LV pressure effort compared to men. Although women had increased LV pressure effort, proxies of myocardial perfusion and work were not affected. |
| Related Links | https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2014.07.003.pdf |
| Ending Page | 204 |
| Page Count | 8 |
| Starting Page | 197 |
| File Format | HTM / HTML |
| ISSN | 18764401 |
| DOI | 10.1016/j.artres.2014.07.003 |
| Journal | Artery Research |
| Issue Number | 4 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2014-08-28 |
| Access Restriction | Open |
| Subject Keyword | Medicine Public Health Pressure wave reflections Blood pressure Women Pulse wave analysis Medicine/Public Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology (medical) Physiology |
| Journal Impact Factor | 0.9/2023 |
| 5-Year Journal Impact Factor | 0.7/2023 |
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