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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Hansen, T. Scholten, B. Hasbak, P. Christensen, T. Ghotbi, A. Kjaer, A. Rossing, P. |
| Abstract | Aims Coronary flow reserve (CFR) and coronary calcium score (CCS) represent different aspects of atherosclerosis. We examined the prevalence and predictors of reduced CFR and high CCS in type 2 diabetes (T2DM) patients free of overt cardiovascular disease compared to non-diabetic controls. Methods Cross-sectional study of 60 T2DM patients stratified by normoalbuminuria (<30mg/24h) (n = 30; age (mean±SD) 60.9±10.1 years; 40% women) and albuminuria (>30mg/24h) (n = 30; 65.6±4.8 years; 27% women) randomly selected from our outpatient clinic and 30 non-diabetic controls (59.8±9.9 years; 40% women) undergoing cardiac 82Rb PET/CT. Results In controls, normoalbuminuric, and albuminuric patients CFR was 3.0±0.8, 2.6±0.8, and 2.0±0.5 (P<0.001); frequency of reduced CFR (<2.5) was 16.7, 40.0, and 83.3% (P<0.001); and CCS (median[IQR]) was 0 [0–81], 36[1–325], and 370[152–1025] (P<0.001), respectively. After comprehensive adjustment, CFR remained significant higher (P = 0.023) and CCS significant lower (P = 0.020) in normoalbuminuric vs. albuminuric patients. The univariate association between CFR and CCS was significant in control subjects (R2 = 0.23; P = 0.007), but not in normoalbuminuric or albuminuric patients (R2≤0.10; P≥0.09). However, after adjustment lower CFR was related to higher CCS, UAER, age, heart rate, lower HbA1C, and male gender (P≤0.047) in albuminuric patients; and to female gender (P = 0.024) in normoalbuminuric patients. Higher CCS was related to lower CFR and UAER (P≤0.048) in albuminuric patients; and to higher HbA1C in controls (P = 0.033). Conclusion T2DM patients free of overt cardiovascular disease had a high prevalence of coronary microvascular dysfunction, especially with concomitant albuminuria. This was not explained by elevated CCS. Prospective studies are needed to show the prognostic significance. |
| Related Links | https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2014.09.114.pdf |
| Ending Page | 137 |
| Page Count | 1 |
| Starting Page | 137 |
| File Format | HTM / HTML |
| ISSN | 18764401 |
| DOI | 10.1016/j.artres.2014.09.114 |
| Journal | Artery Research |
| Issue Number | 4 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2014-11-04 |
| Access Restriction | Open |
| Subject Keyword | Medicine Public Health Medicine/Public Health |
| Content Type | Text |
| Resource Type | Synopsis |
| Subject | Physiology (medical) Physiology |
| Journal Impact Factor | 0.9/2023 |
| 5-Year Journal Impact Factor | 0.7/2023 |
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