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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Van Hoof, R. Hermeling, E. Wijnen, N. Schreuder, F. Truijman, M. Voo, S. Cleutjens, J. Sluimer, J. Heeneman, S. Oostenbrugge, R. Daemen, J.-W. Daemen, M. Wildberger, J. Kooi, M. |
| Abstract | Background Pharmacokinetic modeling in Dynamic Contrast-Enhanced (DCE-)MRI has been introduced to non-invasively assess microvasculature in carotid atherosclerotic plaques, a marker for plaque vulnerability. The main model-parameter, Ktrans, can be assessed in the outer region of the vessel (adventitia) or in the entire vessel wall (including plaque and adventitia) and already showed association with histology and features of plaque vulnerability, respectively. We investigated systematically the correlation between Ktrans of these various regions of the vascular wall and their individual correlation with histology as gold standard. Methods 45 symptomatic patients with 30–99% carotid stenosis underwent 3T DCE-MRI (0.1mmol/kg Gadobutrol, 0.5ml/sec). Quantitative modeling was performed to determine Ktrans of the entire vessel wall, adventitia, and plaque region, separately. For 10 patients, CD31 immunohistochemistry was performed on specimens (containing mainly plaque) removed during carotid endarterectomy to quantify the endothelial microvessel area. Results Adventitial Ktrans showed weak correlation with plaque Ktrans (r=0.64, p<0.001) and was 17.3% higher (p<0.001), coinciding with decreased uncertainty in parameter estimation (p=0.015). Significant positive correlation between the endothelial microvessel area and adventitial Ktrans (r=0.854, p=0.002), but not from the plaque (r=0.438, p=0.2) was observed. Entire vessel wall Ktrans showed intermediate results for the various analyses. Discussion Although Ktrans assessed over various regions within the vascular wall are correlated, absolute values differ significantly. Adventitial Ktrans seems to be a better measure for plaque microvasculature compared to other vascular regions, coinciding with a lower uncertainty in parameter estimation. Comparison with histology in a larger number of patients is recommended for definitive conclusions. |
| Related Links | https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2014.09.097.pdf |
| Ending Page | 133 |
| Page Count | 1 |
| Starting Page | 133 |
| File Format | HTM / HTML |
| ISSN | 18764401 |
| DOI | 10.1016/j.artres.2014.09.097 |
| Journal | Artery Research |
| Issue Number | 4 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2014-11-04 |
| Access Restriction | Open |
| Subject Keyword | Medicine Public Health Medicine/Public Health |
| Content Type | Text |
| Resource Type | Synopsis |
| Subject | Physiology (medical) Physiology |
| Journal Impact Factor | 0.9/2023 |
| 5-Year Journal Impact Factor | 0.7/2023 |
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