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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Van Dijk, S. Smulders, Y. Enneman, A. Swart, K. Van Wijngaarden, J. Ham, A. Van Schoor, N. Dhonukshe-Rutten, R. De Groot, L. Lips, P. Uitterlinden, A. Blom, H. Geleijnse, J. Feskens, E. Van den Meiracker, T. Mattace-Raso, F. Van der Velde, N. |
| Abstract | Background Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old and is also associated with elevated arterial stiffness in this age group. Several intervention trials reported a lack of benefit of B-vitamin supplementation on cardiovascular outcomes, therefore we aimed to investigate the effect of B-vitamin supplementation on arterial stiffness and cardiovascular events in hyperhomocysteinemic elderly subjects. Methods and Results The B-PROOF study is a double-blind randomized-controlled trial, including 2919 elderly (≥ 65 years), with hyperhomocysteinemia (12–50 µmol/l), treated with B-vitamins (500 µg vitamin B12 and 400 µg folic acid) or placebo for 2 years. In a subgroup (n = 569) the effect of B-vitamins on pulse wave velocity (PWV) was investigated. In the total B-PROOF population, incidents of cardiovascular and cerebrovascular events were determined via structured questionnaires and also blood pressure was measured. Compared to placebo, B-vitamins lowered serum homocysteine by 3.6 µmol/L (p<0.001). Analysis of covariance showed no effect of B-vitamins supplementation on PWV levels, but aortic pulse pressure was higher in the intervention than in the placebo group (49.6 mmHg vs. 47.2 mmHg; p = 0.02). Furthermore, a significant reduction of cerebrovascular events in females (OR 0.33 95%CI [0.15 ; 0.71]), but not in males was observed. Conclusions B-vitamins supplementation in hyperhomocysteinemic elderly has no effect on PWV and caused a modest increase in aortic pressure, but also a reduction in cerebrovascular events in females. Arterial stiffness is not likely to be the underlying pathway of the negative trial outcomes. |
| Related Links | https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2014.09.072.pdf |
| Ending Page | 127 |
| Page Count | 1 |
| Starting Page | 127 |
| File Format | HTM / HTML |
| ISSN | 18764401 |
| DOI | 10.1016/j.artres.2014.09.072 |
| Journal | Artery Research |
| Issue Number | 4 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2014-11-04 |
| Access Restriction | Open |
| Subject Keyword | Medicine Public Health Medicine/Public Health |
| Content Type | Text |
| Resource Type | Synopsis |
| Subject | Physiology (medical) Physiology |
| Journal Impact Factor | 0.9/2023 |
| 5-Year Journal Impact Factor | 0.7/2023 |
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