Please wait, while we are loading the content...
| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Alivon, M. Blanchet, B. Vidal, M. Goldwasser, F. Laurent, S. Boutouyrie, P. |
| Abstract | Introduction Antiangiogenic drugs (AAD) are indicated in various solid tumors and induce hypertension. We previously reported a pressure-independent large arteries stiffening under AAD. We hypothesized that large arteries stiffening could be related to the intensity of AAD exposure and that exposure to AAD is related to cancer progression. Methods In this prospective, single center observational study, 61 patients with cancer were included. Peripheral blood pressure and aortic pulse wave velocity (PWV) were performed at baseline and then every two week for two months after the initiation of treatment by sunitinib or sorafenib (V0 to V4). Blood samples were obtained from V1 to V4 for the pharmacokinetic study. Concentrations were determined by HPLC and standardized to combine both drugs (Z-score, mean = 0, SD = 1). Statistical analysis was performed through a robust stepwise regression analysis and Cox regression analysis. Results Mean age was 59(14), mean SBP 127(20) mmHg. At V2, mean BP increased by 5(14) mmHg. Determinants of PWV increase were high AAD blood concentration and mean BP increase (for 1 SD, +0.4 m/s and +0.3m/s respectively, p<0.01). High concentration of AAD during follow-up was associated with a lesser cancer progression and mortality (for 1SD increase, HR: 0.60 [0.38–0.97] and HR: 0.38 [0.19–0.79] respectively, P<0.05, figure1). High AAD and low PWV increase are associated with the lowest cancer progression. Conclusion Large arteries stiffening observed under AAD is proportional to the intensity of exposure to AAD independently of blood pressure increase. Patients under exposed to AAD are at higher risk of disease progression and mortality. |
| Related Links | https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2014.09.079.pdf |
| Ending Page | 129 |
| Page Count | 2 |
| Starting Page | 128 |
| File Format | HTM / HTML |
| ISSN | 18764401 |
| DOI | 10.1016/j.artres.2014.09.079 |
| Journal | Artery Research |
| Issue Number | 4 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2014-11-04 |
| Access Restriction | Open |
| Subject Keyword | Medicine Public Health Medicine/Public Health |
| Content Type | Text |
| Resource Type | Synopsis |
| Subject | Physiology (medical) Physiology |
| Journal Impact Factor | 0.9/2023 |
| 5-Year Journal Impact Factor | 0.7/2023 |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|