NDLI: MiR-140-3p suppressed cell growth and invasion by downregulating the expression of ATP8A1 in non-small cell lung cancer

Content Provider	Springer Nature Link
Author	Dong, Wei Yao, Chunping Teng, Xuepeng Chai, Jie Yang, Xinhua Li, Baosheng
Copyright Year	2015
Abstract	MicroRNAs (miRNAs) as a class of small noncoding RNA molecules regulate the expression of targeted gene. The dysregulation of microRNAs is reported to be involved in carcinogenesis and tumor progression. Here, we identified miR-140-3p as a downregulated microRNA in most cancer tissues including lung cancer tissues, compared with their normal counterparts. MiR-140-3p was observed to perform its tumor suppressor function via its inhibition on cell growth, migration and invasion but its induction of cell apoptosis. Furthermore, the growth of non-small-cell lung cancer (NSCLC) cells in nude mouse models were suppressed by overexpression of miR-140-3p. ATP8A1 was demonstrated as a novel direct target of miR-140-3p using a luciferase assay. The increased level of intracellular ATP8A1 protein attenuated the inhibitor role of miR-140-3p in the growth and mobility of NSCLC cell. A regulation mechanism of miR-140-3p for the development and progression of NSCLC through downregulating the ATP8A1 expression was first discovered in the present study.
Starting Page	2973
Ending Page	2985
Page Count	13
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	3
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-09-28
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Lung cancer MiR-140-3p ATP8A1 Cell proliferation Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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