NDLI: CD20-negative diffuse large B cell lymphoma: a comprehensive analysis of 695 cases

Content Provider	Springer Nature Link
Author	Li, Jing Zhao, Shu Wang, Jingxuan Chen, Jingyu Wen, Wen Zhang, Qingyuan
Copyright Year	2015
Abstract	CD20 expression is absent in a variety of diffuse large B cell lymphomas (DLBCLs), including plasmablastic lymphoma, primary effusion lymphoma, anaplastic lymphoma, kinase-positive DLBCL, and large B cell lymphoma arising in human herpesvirus 8-associated multicentric Castleman disease. These rare and heterogeneous tumors are characterized by the presence of proliferating immunoblasts with similar transcriptional profiles as those of plasma cells and are typically associated with highly aggressive pathologies, with high levels of chemotherapy resistance and low survival rates; thus, they pose significant diagnostic and treatment challenges. We conducted a systematic literature review of the limited existing clinical data to summarize the current knowledge regarding the biological basis, diagnostic limits, and potential therapeutic targets of distinct variants of CD20-negative DLBCL. This review will hopefully increase the awareness of these rare disorders among clinicians and pathologists and prompt basic and clinical research.
Starting Page	3619
Ending Page	3637
Page Count	19
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	3
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-10-12
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	CD20-negative Plasmablastic lymphoma effusion lymphoma ALK-positive DLBCL Multicentric Castleman disease Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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