NDLI: Combination of genetic variants in cyclin D1 and retinoblastoma genes predict clinical outcome in oral cancer patients

Content Provider	Springer Nature Link
Author	Murali, Abitha Varghese, Bipin T. Kumar, R. Rejnish Kannan, S.
Copyright Year	2015
Abstract	Oral cancer is a dreadful disease with a wide variation in geographical distribution. In order to identify some useful biomarkers for the disease prognosis, the present study assessed the influence of single nucleotide polymorphisms (SNPs) in cell cycle genes on survival in a well-annotated set of patients with oral squamous cell carcinoma (OSCC). The study examined 12 sequence variants or SNPs in selected cell cycle genes, with prognostic outcomes in 311 oral cancer patients. Our analysis showed that SNPs in cyclin D1:rs9344 and retinoblastoma:rs427686 genes showed a strong correlation with disease-free survival. In addition, the cumulative effect of these SNPs significantly and independently predicts the survival. Thus, the current study identified genotypes (SNP signature), which can be used as novel prognostic biomarkers to stratify patients based on disease-free survival and therefore maybe helpful in therapeutic decision-making.
Starting Page	3609
Ending Page	3617
Page Count	9
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	37
Issue Number	3
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-10-12
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Cell cycle Single nucleotide polymorphism Oral cancer Prognosis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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