NDLI: Study of the RESS Process for Producing Beclomethasone-17,21-Dipropionate Particles Suitable for Pulmonary Delivery

Content Provider	Springer Nature Link
Author	Charpentier, Paul A. Jia, Ming Lucky, Rahima A.
Copyright Year	2007
Abstract	The purpose of this research was to micronize beclomethasone-17,21-dipropionate (BDP), an anti-inflammatory inhaled corticosteroid commonly used to treat asthma, using the rapid expansion of supercritical solution (RESS) technique. The RESS technique was chosen for its ability to produce both micron particles of high purity for inhalation, and submicron/nano particles as a powder handling aid for use in next generation dry powder inhalers (DPIs). Particle formation experiments were carried out with a capillary RESS system to determine the effect of experimental conditions on the particle size distribution (PSD). The results indicated that the RESS process conditions strongly influenced the particle size and morphology; with the BDP mean particle size decreasing to sub-micron and nanometer dimensions. An increase in the following parameters, i.e. nozzle diameter, BDP mol fraction, system pressure, and system temperature; led to larger particle sizes. Aerodynamic diameters were estimated from the SEM data using three separate relations, which showed that the RESS technique is promising to produce particles suitable for pulmonary delivery.
Starting Page	39
Ending Page	46
Page Count	8
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	9
Issue Number	1
e-ISSN	15309932
Language	English
Publisher	Springer US
Publisher Date	2008-01-08
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	asthma beclomethasone dipropionate crystallization micronization supercritical fluid processing Pharmacology/Toxicology Pharmacy Biochemistry Biotechnology
Content Type	Text
Resource Type	Article

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