NDLI: Investigation of PEGylated Derivatives of Rosin as Sustained Release Film Formers

Content Provider	Springer Nature Link
Author	Nande, V. S. Barabde, U. V. Morkhade, D. M. Joshi, S. B. Patil, A. T.
Copyright Year	2007
Abstract	The purpose of the present study was to investigate the potential use of two PEGylated derivatives of rosin (PD) as sustained release film forming materials. The derivatives differed chemically by their acid numbers—PD-1 with 120.93 and PD-2 with 88.19. The derivative films were characterized for surface morphology, water uptake-weight loss, angle of contact, water vapor transmission rate, mechanical properties and permeability study. Dissolution of diclofenac sodium (DS) and propranolol hydrochloride (PHL) as model drugs was studied from coated pellets. The films of derivatives with and without plasticizers were smooth and continuous. PD-2 films developed greater numbers of pores when in contact with phosphate buffer pH 6.8. The low weight loss, low angles of contact and high water vapor transmission rate of PD-2 films were related to presence of higher concentration of PEG esters. Higher tensile strength and percent elongation of PD-2 films was due to greater degree of internal plasticization of the derivative. The permeability of films to model drugs propranolol hydrochloride and diclofenac sodium was inversely proportional to the film thickness and dibutyl phthalate concentration in them; the permeability being greatest in PD-2 films containing 10% PEG 200. Dissolution rate of propranolol hydrochloride was higher from the coated pellets. The dissolution data followed zero order, Baker–Lonsdale equation and Hixon–Crowell equation of release kinetics with high correlation coefficients. The mechanism of drug release from these coated systems however followed class II transport (n > 1.0). The derivatives investigated could successfully retard release of the model drugs and offers an alternative to the conventionally used polymers.
Starting Page	105
Ending Page	111
Page Count	7
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	9
Issue Number	1
e-ISSN	15309932
Language	English
Publisher	Springer US
Publisher Date	2008-01-16
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	angle of contact PEGylated derivatives permeability release kinetics Pharmacology/Toxicology Pharmacy Biochemistry Biotechnology
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

PEGylated rosin derivatives: Novel microencapsulating materials for sustained drug delivery

Investigation of PEGylated Derivatives of Rosin as Sustained Release Film Formers

Biodegradation and in vivo biocompatibility of rosin: a natural film-forming polymer

Study of novel rosin-based biomaterials for pharmaceutical coating

Sugar End-Capped Poly-d,l-lactides as Excipients in Oral Sustained Release Tablets

Lyophilized Oral Sustained Release Polymeric Nanoparticles of Nateglinide

Evaluation of Mimosa pudica Seed Mucilage as Sustained-Release Excipient

PEGylated Multi-Walled Carbon Nanotubes for Encapsulation and Sustained Release of Oxaliplatin

Mucoadhesive bilayered tablets for buccal sustained release of flurbiprofen

Investigation of PEGylated Derivatives of Rosin as Sustained Release Film Formers

Similar Documents

PEGylated rosin derivatives: Novel microencapsulating materials for sustained drug delivery

Investigation of PEGylated Derivatives of Rosin as Sustained Release Film Formers

Biodegradation and in vivo biocompatibility of rosin: a natural film-forming polymer

Study of novel rosin-based biomaterials for pharmaceutical coating

Sugar End-Capped Poly-d,l-lactides as Excipients in Oral Sustained Release Tablets

Lyophilized Oral Sustained Release Polymeric Nanoparticles of Nateglinide

Evaluation of Mimosa pudica Seed Mucilage as Sustained-Release Excipient

PEGylated Multi-Walled Carbon Nanotubes for Encapsulation and Sustained Release of Oxaliplatin

Mucoadhesive bilayered tablets for buccal sustained release of flurbiprofen

Investigation of PEGylated Derivatives of Rosin as Sustained Release Film Formers