NDLI: Effect of Eudragit$^{®}$ RS 30D and Talc Powder on Verapamil Hydrochloride Release from Beads Coated with Drug Layered Matrices

Content Provider	Springer Nature Link
Author	El Malah, Yasser Nazzal, Sami
Copyright Year	2007
Abstract	The aim of this study was to investigate the effect of Eudragit® RS 30D, talc, and verapamil hydrochloride on dissolution and mechanical properties of beads coated with “drug-layered matrices”. This was accomplished with the aid of a three-factor multiple-level factorial design using percent drug release in 1 and 2 h, T $_{50}$, tensile strength, brittleness, stiffness and toughness as the responses. Beads were coated in a fluidized-bed coating unit. Surface morphology and mechanical properties were evaluated by surface profilometry and texture analysis, respectively. No cracks, flaws and fissures were observed on the surfaces. The mechanical properties were dependent on the talc/polymer ratio. The release of verapamil from the beads was influenced by matrix components. Increasing the level of both talc and Eudragit decreased the percent drug released from 67% to 4.8% and from 80.7% to 6.7% in 1 and 2 h, respectively, and increased T $_{50}$ from 0.8 to 25.7 h. It was concluded that beads could be efficiently coated with “drug-layered matrices”. The release of drug, however, depends on a balance between the levels of drug, talc, and polymer, whereby desired dissolution and mechanical properties could be controlled by the talc/polymer ratio and the level of drug loading.
Starting Page	75
Ending Page	83
Page Count	9
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	9
Issue Number	1
e-ISSN	15309932
Language	English
Publisher	Springer US
Publisher Date	2008-01-09
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	drug layered matrix Eudragit RS 30D fluid bed coating talc powder verapamil hydrochloride Pharmacology/Toxicology Pharmacy Biochemistry Biotechnology
Content Type	Text
Resource Type	Article

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