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Supercritical assisted atomization: A novel technology for microparticles preparation of an asthma-controlling drug

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AAPS PharmSciTech : Volume 6, Issue 2, June 2005

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Supercritical assisted atomization: A novel technology for microparticles preparation of an asthma-controlling drug

Content Provider	Springer Nature Link
Author	Porta, Giovanna Della Vittori, Carlo Reverchon, Ernesto
Copyright Year	2005
Abstract	The objective of this study was to produce microparticles of a new asthma-controlling drug by supercritical assisted atomization (SAA), proposed as an alternative to conventional jet-milling process. SAA is based on the solubilization of supercritical carbon dioxide in a liquid solution containing the drug; the ternary mixture is then sprayed through a nozzle, and microparticles are formed as a consequence of the enhanced atomization. SAA process parameters studied were precipitator temperature, nozzle diameter, and drug concentration in the liquid solution. Their influence was evaluated on morphology and size of precipitated particles. Spherical particles with mean particle size ranging from 1 to 3 μm of the new anti-asthma drug were produced by SAA. The mass median aerodynamic diameter (MMAD) of the SAA micronized particles and of the conventional jet-milled drug was used to compare, the results obtainable using the 2 techniques. Particularly, MMADs from 1.6 to 4.0 μm were obtained by SAA at the optimum operating conditions and by varying the concentration of the solution injected. MMAD of 6.0 μm was calculated for the jet-milled drug. SAA samples also exhibited narrower particle size distribution (PSD). A good control of particle size and distribution together with no drug degradation was obtained by SAA process.
Starting Page	E421
Ending Page	E428
File Format	PDF
Journal	AAPS PharmSciTech
Volume Number	6
Issue Number	3
e-ISSN	15309932
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-01-01
Publisher Institution	American Association of Pharmaceutical Scientists
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	supercritical fluid microparticles carbon dioxide asthma-controlling drug Biotechnology Biochemistry Pharmacy Pharmacology/Toxicology
Content Type	Text
Resource Type	Article

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