NDLI: A simple colorimetric sensor for potassium ion based on DNA G-quadruplex conformation and salt-induced gold nanoparticles aggregation

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Analytical Methods Vol - 6 Issue - 9

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A simple colorimetric sensor for potassium ion based on DNA G-quadruplex conformation and salt-induced gold nanoparticles aggregation

Content Provider	Royal Society of Chemistry (RSC)
Author	Guo, Junxia Ma, He Zhou, Tong Chen, Zhengbo Li, Xiaoxiao
Copyright Year	2014
Abstract	A simple colorimetric sensor for potassium ions (K+) based on DNA G-quadruplex conformation and salt-induced gold nanoparticle (AuNP) aggregation was developed. In the presence of K+ and NaCl, the conformation of the anti-K+ aptamer changed from a random coil structure to a G-quadruplex one, and this rigid G-quadruplex structure lost the ability to protect AuNPs from salt-induced aggregation; thus, the color change of AuNPs from wine red to blue could be observed by the naked eye. The aptasensor showed that the analytical linear range was from 1 μM to 1 mM and the detection limit was 0.42 nM. The presence of other metal ions did not affect the detection of K+, which indicated an excellent specificity of K+ detection. Rapidity, simplicity, high sensitivity and excellent selectivity made it suitable for practical use in determination of K+ in real urine samples.
Starting Page	8018
Ending Page	8021
Page Count	4
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	6
Issue Number	19
Journal	Analytical Methods
DOI	10.1039/c4ay01025f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Wine Urine Nanoparticle DNA G-quadruplex Aptamer Random coil Potassium
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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