NDLI: Reliable identification and quantification of three diethylphenethylamines in a <i>Dendrobium</i>-based dietary supplement

Content Provider	Royal Society of Chemistry (RSC)
Author	Styles, C. Wahlstrom, R. Hägglund, G.
Copyright Year	2014
Abstract	An analytical method has been developed for the identification and quantification of N,α-diethyl-phenylethylamine, N,N-diethyl-phenylethylamine and N,β-diethyl-phenylethylamine (N,α-DEPEA, N,N-DEPEA and N,β-DEPEA, respectively) in a pre-workout dietary supplement containing extract from orchids of the Dendrobium genus. UHPLC-MS/MS (QQQ) technology was utilized for identification and quantitation using custom synthesized external standards as references. In less than 9 minutes the method successfully identifies N,α-DEPEA, N,N-DEPEA and N,β-DEPEA down to 0.1 ng ml−1 and quantifies the same substances down to 0.3 ng ml−1. The method proved to be rapid, stable and reproducible with good separation and detection limits. N,β-DEPEA proved difficult to be separated from N,α-DEPEA both chromatographically and mass spectrometry-wise due to the notable differences in concentration and their structural similarity. The presence of N,β-DEPEA in the analyzed sample type has not been studied in previously published results, thus this study adds to the current scientific interest in characterizing the contents of certain pre-workout dietary supplements. The amounts found in the products vary between batches, but were found to be around 2 mg g−1 for N,β-DEPEA, 0.3–4 μg g−1 for N,α-DEPEA and 60–230 ng g−1 for N,N-DEPEA.
Starting Page	7891
Ending Page	7897
Page Count	7
File Format	HTM / HTML PDF
ISSN	17599660
Volume Number	6
Issue Number	19
Journal	Analytical Methods
DOI	10.1039/c4ay01452a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Dietary supplement Dendrobium Genus Size-exclusion chromatography
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Engineering Chemical Engineering

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