NDLI: Implantable probe with split anchors via residual stress and induced cell growth with gelatin nanofibres

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Implantable probe with split anchors via residual stress and induced cell growth with gelatin nanofibres

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The Journal of Engineering

Implantable probe with split anchors via residual stress and induced cell growth with gelatin nanofibres

Content Provider	IET Digital Library
Author	Chen, Yu Yen Chen, Bo An Tsai, Daniel Huang, Cheng Chun Yu, Jiashing Shih, Wen Pin Lin, Chii Wann
Abstract	A bipolar electrode probe used for implantable nerve stimulation treatments in minimally invasive surgeries is presented. The probe is composed of a flexible printed circuit substrate and a patterned SU-8 film. This probe features a three-dimensional (3D) tweezer-like mechanism opened by residual stress from the SU-8 film, designed to fix the probe in the tissue surrounding a target nerve. Stripes on the SU-8 film direct the net residual stress in a single direction to form a curve. The holding strengths of the probes with different deformations are defined and measured by a tensile test. Results show that the fixing ability of a 3D probe is better than a plane probe. The probes with curvature heights between 13 and 14 mm have a maximum average breaking force of 0.258 N, which is 16.3 and 13.1% higher than the probes with curvature heights between 9 and 10 mm and between 10 and 11 mm, respectively. In addition, a film of gelatin fibrous membrane, produced by electrospinning, covers the fixed ends of the probe's anchors and acts as cell scaffolds to induce cell growth, which help to ensure long-term fixation in the body. 3T3 fibroblast cells are grown to verify the scaffold effect of the fibrous membrane.
Starting Page	901
Ending Page	905
Page Count	5
Volume Number	9
e-ISSN	17500443
Issue Number	Issue 12, Dec (2014)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/mnl/9/12
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/mnl.2014.0447
Journal	Micro & Nano Letters
Publisher Date	2014-12-10
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	3D Probe 3T3 Fibroblast Cells Bioelectric Phenomena Bioelectric Signal Bioelectricity Biological Tissues Biological Transport Biomechanics Biomedical Electrodes Biomedical Material Bipolar Electrode Probe Cell Scaffolds Cellular And Subcellular Transmembrane Physics Cellular Biophysics Curvature Heights Deformation Deformation And Plasticity Dialysis Electrical Activity in Neurophysiological Processes Electro Osmosis Electro spinning Film And Membrane Processes Fixing Ability Flexible Electronics Flexible Printed Circuit Substrate Gelatin Gelatin Fibrous Membrane Gelatin Nanofibre Gels And Sols Holding Strengths Implantable Nerve Stimulation Treatments Implantable Probe Induced Cell Growth Internal Stresses Ion Exchange Long-term Fixation Material Testing Maximum Average Breaking Force Mechanical Property of Tissues And Organs Membranes Method of Nanofabrication And Processing Minimally Invasive Surgeries Nanofabrication Nanofibre Nanomedicine NanoParticle Nanotechnology Application in Biomedicine Nanotube And Nanostructured Material Natural And Artificial Biomembranes Net Residual Stress Neurophysiology Orthotics Osmosis Patient Care And Treatment Patterned SU-8 Film Plane Probe Plasticity And Creep Printed Circuit Prosthetics Prosthetics And Other Practical Application Size 13 Mm to 14 Mm Size 9 Mm to 11 Mm Split Anchors Structure of Solid Clusters Surfactant Tensile Test Tensile Testing Three-dimensional Tweezer-like Mechanism Tissue
Content Type	Text
Resource Type	Article

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