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| Content Provider | IET Digital Library |
|---|---|
| Author | Sivashankar, Shilpa Agambayev, Sumeyra Alamoudi, Kholod Buttner, Ulrich Khashab, Niveen Salama, Khaled Nabil |
| Abstract | The salient features of microfluidics such as reduced cost, handling small sample and reagent volumes and less time required to fabricate the devices has inspired the present work. The incompatibility of three-dimensional printer resins in their native form and the method to improve their compatibility to many biological processes via surface modification are reported. The compatibility of the material to build microfluidic devices was evaluated in three different ways: (i) determining if the ultraviolet (UV) cured resin inhibits the polymerase chain reaction (PCR), i.e. testing devices for PCR compatibility; (ii) observing agglutination complex formed on the surface of the UV cured resin when anti-C-reactive protein (CRP) antibodies and CRP proteins were allowed to agglutinate; and (iii) by culturing human embryonic kidney cell line cells and testing for its attachment and viability. It is shown that only a few among four in its native form could be used for fabrication of microchannels and that had the least effect on biological molecules that could be used for PCR and protein interactions and cells, whereas the others were used after treating the surface. Importance in building lab-on-chip/micrototal analysis systems and organ-on-chip devices is found. |
| Starting Page | 654 |
| Ending Page | 659 |
| Page Count | 6 |
| Volume Number | 11 |
| e-ISSN | 17500443 |
| Issue Number | Issue 10, Oct (2016) |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/mnl/11/10 |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/10.1049/mnl.2016.0530 |
| Journal | Micro & Nano Letters |
| Publisher | The Institution of Engineering and Technology |
| Publisher Date | 2016-10-01 |
| Access Restriction | Open |
| Rights License | Creative Commons Attribution-Non Commercial-No Derivs License (http://creativecommons.org/licenses/by-nc-nd/3.0/) |
| Subject Keyword | Agglutination Complex AntiC-reactive Protein Antibodies Biochemistry Biological Technique BioMEMS Biophysical Instrumentation And Technique Cellular Biophysics Compatibility Analysis CRP Proteins Curing Elastomers Enzymes Fabrication of MEMS And NEMS Device Human Embryonic Kidney Cell Line Kidney Lab-on-chip-micrototal Analysis Microchannel Fabrication Microfabrication Microfluidic Device Microfluidics Micromechanical And Nanomechanical Device And System Molecular Biophysics Organ-on-chip Device PCR Compatibility Physical Chemistry of Biomolecular Solutions And Condensed State Plastics Polymerase Chain Reaction Preparation of Polymers And Plastics Protein Interactions Resins Structure of Polymers Surface Topography Measurement Surface Treatment And Degradation of Polymers And Plastics Three-dimensional Printer Resins Ultraviolet Cured Resin UV Cured Resin |
| Content Type | Text |
| Resource Type | Article |
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