NDLI: The use of nano-structured hybrid materials for oral drug delivery

Content Provider	IEEE Xplore Digital Library
Author	Kumar, R. Cheang, P. Hariram, K.P. Aik, K.K.
Copyright Year	2006
Description	Author affiliation: Montana Tech. of the Univ. of Montana, Butte (Kumar, R.)
Abstract	We have used a novel hybrid nano-structured sponge to conduct proof of concept studies for the oral delivery of peptides employing insulin as the loaded model drug. The hybrid sponge was synthesized from a modified acid-base neutralization reaction for hydroxyapatitc (HA) incorporating cMtosan (CHT) as the organic counterpart. The trace addition of chitosan during synthesis resulted in a hybrid colloidal suspension which could be dried to from this hybrid sponge. The sponge morphology was unique indicating two levels of structure with assembled nanoparticles combined with nanoporous HA-CHT architecture. These films showed relatively high levels of insulin loading (~700IU/g of carrier) and could be coated with an alginate based gel. Release of insulin in simulated gastric and intestinal fluids (SGF and SIF) indicated that release was predominant in intestinal conditions and that a complex double mode kinetic release profile was inherent in the system. However, we believe at this stage that this characteristic can be rationalized as the combined effect of release from the drug adsorbed onto the nanoparticles and condensed into the nanoporous architecture. Overall the loading and release were promising and further studies are currently underway to incorporate other functional modifications in the sponge and in vitro characterization.
Starting Page	494
Ending Page	499
File Size	990658
Page Count	6
File Format	PDF
ISBN	9789810579
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-12-11
Publisher Place	Singapore
Access Restriction	Subscribed
Rights Holder	NTU
Subject Keyword	Nanoparticles Intestines Peptides Morphology Drug delivery Nanoporous materials Nanostructured materials Insulin Conducting materials Load modeling
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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