NDLI: Grinding effect on the thermodynamic and kinetic characterizations of polymorphic transformation of famotidine

Content Provider	IEEE Xplore Digital Library
Author	Shan-Yang Lin Wen-Ting Cheng Mei-Jane Li Shun-Li Wang
Copyright Year	2006
Description	Author affiliation: Taipei Veterans Gen. Hosp., Taipei (Shan-Yang Lin; Wen-Ting Cheng; Mei-Jane Li)
Abstract	Two polymorphs of famotidine, forms A and B, were prepared. The raw material of famotidine used in this study was proved to be a form B. Each famotidine sample ground for different grinding times in a ceramic mortar was determined by differential scanning calorimetry (DSC), Raman and thermal Fourier transform infrared (FT-IR) microspectroscoies, respectively. The effect of grinding process on the polymorphic transformation of famotidine from form B to form A was investigated. The peak intensity of a unique Raman band at 2897 $cm^{-1}$ for form B gradually decreased with the grinding time, while the new Raman band at 2920 $cm^{-1}$ for form A slowly appeared. The Raman peak intensity ratio of 2897 $cm^{-1}/2920$ $cm^{-1}$ was linearly decreased with the grinding time (r = 0.99), suggesting that the grinding process could induce the polymorphic transformation of famotidine from form B to form A. The DSC endothermic peaks also confirmed this polymorphic transformation from form B (167degC, DeltaH: 55.68 KJ/mole) to form A (174degC, DeltaH: 49.94 KJ/mole), in which the values of enthalpy were linearly reduced with the increase of grinding time (r = 0.99). The phase transition temperature of the different famotidine ground samples was easily and solely evidenced by using thermal FT-IR microspectroscopy, rather than by DSC analysis. These phase transition temperatures of the form B was maintained to a constant even after 20-30 min grinding. The present study indicates that the grinding process can easily induce the polymorphic transformation of famotidine from form B to form A with a zero-order kinetic.
Starting Page	314
Ending Page	318
File Size	2310659
Page Count	5
File Format	PDF
ISBN	9789810579
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-12-11
Publisher Place	Singapore
Access Restriction	Subscribed
Rights Holder	NTU
Subject Keyword	Drugs Thermodynamics Fourier transforms Manufacturing processes Hospitals Microscopy Kinetic theory Infrared spectra Land surface temperature Pharmaceuticals
Content Type	Text
Resource Type	Article

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