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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Holmes, D. Tao Sun Morgan, H. Holloway, J. Cakebread, J. Davies, D. |
| Copyright Year | 2007 |
| Description | Author affiliation: Univ. of Southampton, Southampton (Holmes, D.; Tao Sun; Morgan, H.) |
| Abstract | Impedance spectroscopy is a non-invasive technique which allows analysis of the electrical properties of biological cells and other materials. Typically, the electrical properties of a cell suspension are measured using relatively large volumes (>100 mul). This approach suffers from the significant drawback that the measurement is averaged over several million cells, and as such, discrimination of cell sub-population and cell sorting is impossible. We have developed a microfluidic device capable of high-speed impedance analysis of individual cells in rapid succession. In this paper, we outline the theory for impedance analysis of a single cell in a microchip. We show experimentally, the ability of the technology to distinguish, based on impedance alone, the three main leukocyte (white blood cell) sub-populations (monocytes, lymphocytes, neutrophils) in human blood. Fluorescence analysis of the cells is performed simultaneously with impedance measurement, as cells flow through the device. This provides a direct correlation between cell type (based on antibody) and impedance properties. The data shows distinct differences in the impedance properties of leukocyte sub-populations at specific frequencies. |
| Starting Page | 1452 |
| Ending Page | 1455 |
| File Size | 705740 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424412617 |
| ISSN | 19300395 |
| DOI | 10.1109/ICSENS.2007.4388687 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2007-10-28 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | White blood cells Electrochemical impedance spectroscopy Biological cells Biological materials Electric variables measurement Volume measurement Sorting Microfluidics Humans Fluorescence |
| Content Type | Text |
| Resource Type | Article |
| Subject | Electrical and Electronic Engineering |
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