NDLI: Robotic cell manipulation with optical tweezers for biomechanical characterization

Content Provider	IEEE Xplore Digital Library
Author	Youhua Tan Dong Sun Shuk Han Cheng Li, R.A.
Copyright Year	2011
Description	Author affiliation: Department of Medicine, the University of Hong Kong, China (Li, R.A.) \|\| Department of Manufacturing Engineering and Engineering Management, City University of Hong Kong, China (Youhua Tan; Dong Sun) \|\| Department of Biology and Chemistry, City University of Hong Kong, China (Shuk Han Cheng)
Abstract	In this paper, we demonstrate the effectiveness of robotic cell stretching with optical tweezers for biomechanical characterization. Optical traps serve as end-effectors to manipulate micro-beads attached to the cell surface. The dynamics of the cell-bead mixture during cell stretching is investigated for the first time. Based on our previous work, cell stiffness is extracted and biomechanical properties of cells can be characterized. Our study shows that the modeling results agree with the experimental data. Further, the area compressibility moduli of two types of cells, human embryonic stem cells (hESC) and hESC-derived cardiomyocytes (hESC-CM), are characterized. The results indicate that undifferentiated stem cells are much softer than differentiated ones, which provides an important insight into the cell mechanics during hESC differentiation. In summary, this paper successfully demonstrates that the robot-tweezer system can manipulate biological cells effectively to characterize biomechanical properties of living cells.
Starting Page	4104
Ending Page	4109
File Size	457451
Page Count	6
File Format	PDF
ISBN	9781612843865
ISSN	10504729
e-ISBN	9781612843858
DOI	10.1109/ICRA.2011.5979577
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-05-09
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Charge carrier processes Biomedical optical imaging Force Optical imaging Optical feedback Optical sensors Mathematical model
Content Type	Text
Resource Type	Article
Subject	Artificial Intelligence Control and Systems Engineering Electrical and Electronic Engineering Software

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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