NDLI: Registration methods for histological slides and ex vivo MRI of prostate

Content Provider	IEEE Xplore Digital Library
Author	Hyunjin Park Kwee, S. Thibault, G.P. Stack, R. Sesterhenn, I.A. Potter, K. Meyer, C.R.
Copyright Year	2007
Description	Author affiliation: Univ. of Michigan, Ann Arbor (Hyunjin Park)
Abstract	A methodology for registering histological slides and ex vivo MRI of prostate is proposed. After such registration is performed, spatial correspondence between histology slides and ex vivo MRI is established, thus histological truth can be propagated to the ex vivo MRI space. We employ the well established registration approach based on mutual information (MI) and thin-plate splines (TPS), which is automatic after user's initial placement of control points. Directly registering histology slides onto ex vivo MRI is challenging because 1) it is a difficult 2D (slice) to 3D (volume) registration problem and 2) there is a big difference in information content as histology slides are typically taken at much higher resolution than ex vivo MRI. Here we propose to overcome this challenge by breaking the difficult direct registration task into easier registration sub-tasks. For this purpose, we acquire digital photographs of prostate specimen as it is sectioned, which are referred to as block face photos. First, we register histology slides onto block face photos and then register block face photos onto ex vivo MRI. Results from two registrations tasks are combined to establish registration between histology slides and ex vivo MRI. Before the second registration task, we stack the block face photos into a volume so that registration onto the ex vivo MRI is a more stable 3D (volume) to 3D (volume) registration.
Starting Page	3102
Ending Page	3104
File Size	431478
Page Count	3
File Format	PDF
ISBN	9781424409228
ISSN	10957863
DOI	10.1109/NSSMIC.2007.4436786
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic resonance imaging In vivo Mutual information Probability density function Nuclear and plasma sciences Automatic control Distributed computing Gray-scale Histograms Prostate cancer
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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