NDLI: A silicon SPECT system for molecular imaging of the mouse brain

Content Provider	IEEE Xplore Digital Library
Author	Shokouhi, S. Fritz, M.A. McDonald, B.S. Durko, H.L. Furenlid, L.R. Wilson, D.W. Peterson, T.E.
Copyright Year	2007
Description	Author affiliation: Vanderbilt Univ., Nashville (Shokouhi, S.; Fritz, M.A.; McDonald, B.S.)
Abstract	We previously demonstrated the feasibility of using silicon double-sided strip detectors (DSSDs) for SPECT imaging of the activity distribution of iodine-125 using a 300-micrometer thick detector. Based on this experience, we now have developed fully customized silicon DSSDs and associated readout electronics with the intent of developing a multi-pinhole SPECT system. Each DSSD has a 60.4 mm x 60.4 mm active area and is 1 mm thick. The strip pitch is 59 micrometers, and the readout of the 1024 strips on each side gives rise to a detector with over one million pixels. Combining four high-resolution DSSDs into a SPECT system offers an unprecedented space-bandwidth product for the imaging of single-photon emitters. The system consists of two camera heads with two silicon detectors stacked one behind the other in each head. The collimator has a focused pinhole system with cylindrical-shaped pinholes that are laser-drilled in a 250 mum tungsten plate. The unique ability to collect projection data at two magnifications simultaneously allows for multiplexed data at high resolution to be combined with lower magnification data with little or no multiplexing. With the current multi-pinhole collimator design, our SPECT system will be capable of offering high spatial resolution, sensitivity and angular sampling for small field-of-view applications, such as molecular imaging of the mouse brain.
Starting Page	2782
Ending Page	2784
File Size	236552
Page Count	3
File Format	PDF
ISBN	9781424409228
ISSN	10957863
DOI	10.1109/NSSMIC.2007.4436717
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Silicon Molecular imaging Mice Detectors Decision support systems Strips Head Collimators Spatial resolution Readout electronics
Content Type	Text
Resource Type	Article

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