NDLI: Investigation of effects of volume-of-interest mis-registration on accuracy of organ activity estimates obtained with quantitative planar processing

Content Provider	IEEE Xplore Digital Library
Author	Song, N. He, B. Frey, E.C.
Copyright Year	2007
Description	Author affiliation: Johns Hopkins Univ., Baltimore (Song, N.; He, B.; Frey, E.C.)
Abstract	In targeted radionuclide therapy (TRT), dose estimation is essential for treatment planning and tumor dose response studies. Dose estimates are typically based on whole body conjugate view planar or SPECT imaging of the patient after administration of a planning dose. Quantifying the activity in the organs from these studies is an essential part of dose estimation. The Quantitative Planar (QPlanar) processing method involves both accurate compensation for image degrading factors and correction of overlap from background and organs. It thus provides more accurate activity estimates than traditional planar activity estimation methods. However, alignment between the 3D organ volume of interest (VOIs) used in QPlanar processing and the true organ projections in the planar images is required in this method. The goal of this research was to study the effects of misregistration of VOIs on the accuracy and precision of organ activity estimates obtained using the QPlanar method. In this work, we modeled the degree of mis-registration that would be expected clinically. Mutual information based image registration was implemented to align realistic simulated 3D SPECT images that can be used to define 3D organ VOIs with 2D planar images. The resulting model of image mis-registration was applied to study the effects of mis-registration on the QPlanar method.
Starting Page	3105
Ending Page	3108
File Size	188627
Page Count	4
File Format	PDF
ISBN	9781424409228
ISSN	10957863
DOI	10.1109/NSSMIC.2007.4436787
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mutual information Medical treatment Neoplasms Degradation Image registration Attenuation Nuclear and plasma sciences Helium Process planning Maximum likelihood estimation
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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