NDLI: Simulation of a pinhole-collimator insert for small animal PET using GATE

Content Provider	IEEE Xplore Digital Library
Author	Zixiong Cao Cardi, C.A. Acton, P.D. Thakur, M.L.
Copyright Year	2007
Description	Author affiliation: Thomas Jefferson Univ., Philadelphia (Zixiong Cao; Cardi, C.A.; Acton, P.D.; Thakur, M.L.)
Abstract	In previous work we demonstrated the feasibility to conduct SPECT imaging using a multi-pinhole collimator insert in a small animal PET scanner. A simplified analytical simulation method was used, modeling mainly geometric attributes, to optimize the multi-pinhole configuration to achieve the best trade-off between resolution and sensitivity for specific applications. To more accurately optimize the pinhole configuration more physical attributes need to be modeled, including attenuation and scatter in both the object and collimator. In this work we used GATE, a Monte Carlo simulation platform based on the well-validated Geant4 libraries, to better model our system. New simulations have been performed using the geometry of the MOSAIC (Philips) system and our simple prototype cylindrical insert (lead, 12 pinholes, pinhole diameter 1.0 mm, insert diameter 60 mm). Measurements of sensitivity (0.22%), resolution (FWHM=1.6 mm), and scatter fraction (28%) using point and capillary sources from GATE-simulated data are in good agreement with measured experimental data. Having validated this simulation environment with this baseline test, we are iteratively testing various objects, pinhole configurations, and collimator materials to design our next generation of optimal pinhole configurations for specific imaging tasks.
Starting Page	2933
Ending Page	2936
File Size	710354
Page Count	4
File Format	PDF
ISBN	9781424409228
ISSN	10957863
DOI	10.1109/NSSMIC.2007.4436748
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Animals Positron emission tomography Collimators Solid modeling Scattering Materials testing Analytical models Optimization methods Attenuation Libraries
Content Type	Text
Resource Type	Article

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