NDLI: Design optimization of the PMT-ClearPET prototypes based on simulation studies with GEANT3

Content Provider	IEEE Xplore Digital Library
Author	Heinrichs, U. Pietrzyk, U. Ziemons, K.
Copyright Year	2003
Description	Author affiliation: Zentrallabor fur Elektron., Forschungszentrum Julich GmbH, Germany (Heinrichs, U.)
Abstract	Within the Crystal Clear Collaboration four centres are developing 2/sup nd/ generation high performance small animal PET scanners for different kinds of animals and medical applications. The first prototypes are PMT-based systems including depth of interaction (DOI) detection by using a phoswich layer of LSO and LuYAP. The aim of these simulation studies is to optimize sensitivity and spatial resolution of given designs, which vary in FOVs caused by different detector configurations (ring/octagon) and sizes. For this purpose the simulation tool GEANT3 (CERN) was used. The simulations have shown that all PMT designs with one-to-one coupling of crystals have a very nonlinear axial sensitivity profile. By shifting every other PMT 1/4 of a PMT length in axial direction the sampling of the FOVs became more homogeneous. At an energy threshold of 350keV the regression coefficient increases from 0.818 for the non-shifted to 0.993 for the shifted design. Simulations of a point source centred in the FOV (threshold: 350keV) resulted in sensitivities of 4.2% for a 4/spl times/20PMT (LSO/LuYAP a 10mm) and 3.8% for a 4/spl times/16PMT (LSO/LuYAP a 8mm) ring design. The 3D-MLEM reconstruction of a point source shows the enormous improvement of resolution using a crystal double layer with DOI (3.1mm at 40mm from CFOV) instead of a 20mm single layer (11.9mm).
Starting Page	682
Ending Page	686
File Size	771295
Page Count	5
File Format	PDF
ISBN	0780376366
DOI	10.1109/NSSMIC.2002.1239415
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-11-10
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Design optimization Virtual prototyping Medical simulation Animals Collaboration Positron emission tomography Medical services Biomedical equipment Prototypes Spatial resolution
Content Type	Text
Resource Type	Article

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