NDLI: Impact of scatter correction in the kinetic analysis of a D2 receptor ligand SPECT study

Content Provider	IEEE Xplore Digital Library
Author	Kyeong Min Kim Watabe, H. Shidahara, M. Onishi, Y. Yonekura, Y. Iida, H.
Copyright Year	2002
Description	Author affiliation: Dept. of Investigative Radiol., Nat. Cardiovascular Center-Res. Inst., Osaka, Japan (Kyeong Min Kim; Watabe, H.)
Abstract	Scatter correction (SC) has been shown to be essential for the quantification of brain perfusion in SPECT. However, in the case using the tracer showing a high activity accumulation in a small region with only a small activity in other areas of brain, the contribution of SC has yet to be studied. In this work, the impact of SC on the quantitative kinetic parameters derived from SPECT studies using a dopamine D2 receptor ligand was investigated. SPECT data were acquired dynamically with serial arterial blood sampling following intravenous injection of I-123 iodobezofuran (IBF). SC was performed with the previously validated transmission dependent convolution subtraction (TDCS) technique. Images were reconstructed by OSEM including the attenuation correction (AC), and FBP with post AC by Chang's method. Time activity curves (TACs) were generated from the striatum (STR) and occipital lobe (OCC) regions, with and without SC. Quantitative values of binding potential (BP) were then compared for four kinetic models, including the 3 compartment model (3COM), linear graphic plot (GRP), reference tissue method (RTM), and multi-regression method (MLR). SC changed both TACs of STR and OCC, and introduced significant changes in kinetic parameters, which induced the significantly increased BP in 4 kinetic models, compared to those without SC. The change in BP by SC was greater with 3COM model, than the other models. SC caused significant change in the shape of TACs in both STR and OCC, resulting in increased BP with all four kinetic methods. Likewise for the brain perfusion study, SC is required for the dopamine D2 receptor ligand studies in SPECT.
Starting Page	1509
Ending Page	1512
File Size	1530153
Page Count	4
File Format	PDF
ISBN	0780373243
ISSN	10823654
DOI	10.1109/NSSMIC.2001.1008624
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2001-11-04
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Scattering Kinetic theory Brain modeling Blood Image sampling Convolution Image reconstruction Attenuation Graphics Shape
Content Type	Text
Resource Type	Article

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