NDLI: Modeling the respiratory motion of solitary pulmonary nodules for investigating SPECT tumor imaging

Content Provider	IEEE Xplore Digital Library
Author	Smyczynski, M.S. Segars, W.P. Narayanan, M.V. Pretorius, P.H. Gifford, H.C. Farncombe, T.H. Hoffman, E.A. Tsui, B.M.W. King, M.A.
Copyright Year	2002
Description	Author affiliation: Div. of Nucl. Medicine, Massachusetts Univ. Med. Center, Worcester, MA, USA (Smyczynski, M.S.)
Abstract	We have modeled the respiratory motion of solitary pulmonary nodules (SPN) based on the change of location of anatomic structures in the lungs determined from breath-held CT images of volunteers acquired at two different stages of respiration. The resulting 3D data was visualized in summed coronal, sagittal, and transaxial projections by drawing an arrow showing the direction and magnitude of motion during inspiration. The findings reveal that there is a three-dimensional component of the motion of structures within the lung and that the magnitude and direction vary based on the specific anatomic region of the lung. This information on respiratory motion within the lungs was combined with the NCAT phantom to allow the creation of source and attenuation maps for investigating the impact of respiratory motion in single photon emission computed tomographic (SPECT) imaging for SPN with Tc-99m labeled NeoTect. With the source and attenuation distribution thus defined, the SIMIND Monte Carlo program is used to produce SPECT projection images for the normal background Tc-99m NeoTect distribution and each of the tumors separately. These projections can be combined according to the desired tumor contrast and employed to investigate the impact of respiratory motion of SPN detection using human-observer localization receiver operating characteristics (LROC) studies.
Starting Page	1371
Ending Page	1375
File Size	857933
Page Count	5
File Format	PDF
ISBN	0780373243
ISSN	10823654
DOI	10.1109/NSSMIC.2001.1008592
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2001-11-04
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Neoplasms Lungs Attenuation Computed tomography Data visualization Imaging phantoms Single photon emission computed tomography Optical computing Monte Carlo methods Motion detection
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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