NDLI: Human [/sup 123/I]5-I-A-85380 dynamic SPECT studies in normals: kinetic analysis and parametric imaging

Content Provider	IEEE Xplore Digital Library
Author	Yun Zhou Brasic, J.R. Musachio, J.L. Zukin, S.R. Kuwabara, H. Crabb, A.H. Endres, C.J. Hilton, J. Hong Fan Wong, D.F.
Copyright Year	2002
Description	Author affiliation: Dept. of Radiol., Johns Hopkins Univ., Baltimore, MD, USA (Yun Zhou; Brasic, J.R.; Musachio, J.L.; Zukin, S.R.; Kuwabara, H.; Crabb, A.H.; Endres, C.J.; Hilton, J.; Hong Fan; Wong, D.F.)
Abstract	[/sup 123/I]5-I-A-85380 ([/sup 123/I]5-IA) is a ligand specific for the /spl alpha/4/spl beta/2 nicotinic acetylcholine receptor (nAChR) subtype. It was reported that distribution volume (DV) is an appropriate measurement for /spl alpha/4/spl beta/2 nAChR density in baboon [/sup 123/I]5-IA dynamic SPECT studies. To evaluate the kinetics obtained from human [/sup 123/I]5-IA dynamic SPECT, three different methods were applied to region of interest (ROI) kinetics analysis as follows: A: a 2-compartment 3-parameters model, B: 3-compartment 5-parameter model, and C: same model as in B but fitting with a constraint of ratio of K/sub 1//k/sub 2/e estimated by fitting occipital kinetics to model in A. The DV was estimated as DV= K/sub 1//k/sub 2/ for A, and DV=(K/sub 1//k/sub 2/)(1+k/sub 3//k/sub 4/) for B and C. Nonlinear least squares fitting using Marquardt algorithm was performed for A-C. Akaike information criterion (AIC) and R/sup 2/ were used for evaluation of fitting results. A linear parametric imaging algorithm derived from model in method A was used for generating images of K/sub 1/ and DV. Four normal human [/sup 123/I]5-IA dynamic studies were evaluated by A-C. In each study, after a bolus of [/sup 123/I]5-IA (5/spl sim/10 mCi, specific activity>10 Ci/umol) was injected intravenously, a dynamic scanning with 20 acquisitions over 6 hour was started immediately on a Trionix TriadXLT scanner. 30-40 arterial plasma samples were taken during the study and HPLC was performed to determine the metabolite-corrected arterial plasma radioactivity as input function. The ROI regions (cerebellum, frontal cortex, occipital cortex, pones, and thalamus) were drawn on co-registered MRI images. Results show that A fits to all ROI kinetics very well (R/sup 2/>0.99), and paired T-test for AIC showed there is no statistical significantly improvement of model fitting from B, C methods. The K/sub 1/ and DV images are of good image quality. Conclusion: A is best for ROI kinetic analysis and parametric imaging for DV and K/sub 1/.
Starting Page	1335
Ending Page	1340
File Size	298704
Page Count	6
File Format	PDF
ISBN	0780373243
ISSN	10823654
DOI	10.1109/NSSMIC.2001.1008584
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2001-11-04
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Humans Kinetic theory Plasmas Density measurement Volume measurement Performance analysis Algorithm design and analysis Least squares approximation Performance evaluation Image generation
Content Type	Text
Resource Type	Article

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