NDLI: Imaging the unanesthetized rat brain with PET: a feasibility study

Content Provider	IEEE Xplore Digital Library
Author	Vaska, P. Schlyer, D.J. Woody, C.L. Stoll, S.P. Radeka, V. Volkow, N.
Copyright Year	2002
Description	Author affiliation: Brookhaven Nat. Lab., Upton, NY, USA (Vaska, P.; Schlyer, D.J.; Woody, C.L.; Stoll, S.P.; Radeka, V.; Volkow, N.)
Abstract	The current requirement of anesthesia in PET imaging of animals has undesirable effects on the study of neurological systems and limits the types of studies that can be performed. To enable functional studies of the unanesthetized rat brain, the feasibility of a miniaturized PET tomograph that is secured directly to the head of the rat while allowing collective motion of the head and scanner, has been investigated. The proposed geometry is a septa-less, 4 cm-diameter ring tomograph with an axial extent of 2 cm, that fits between the eyes and ears of a typical laboratory rat, positioning nearly the entire brain within the field of view. This geometry allows a normal posture and can be affixed with techniques currently used to secure microdialysis probes in the rat brain. The proposed detectors are state-of-the-art, but commercially available arrays of 2/spl times/2/spl times/10 mm/sup 3/ LSO crystals and matching avalanche photodiode arrays. A realistic mockup of the scanner weighing 125 g was tested on a rat and tolerated well. Studies have been carried out to estimate the performance characteristics of the proposed scanner, which are compared to those of the rodent microPET systems (UCLA prototype and commercial Concorde scanners). The parallax contribution to the spatial resolution at the edge of the brain can be reduced to microPET levels by using 2 layers of 5 mm-long crystals. Sensitivity, deadtime/countrate capability, scatter, and randoms from activity outside the field of view are estimated to be comparable to the microPET systems as well.
Starting Page	1569
Ending Page	1571
File Size	442566
Page Count	3
File Format	PDF
ISBN	0780373243
ISSN	10823654
DOI	10.1109/NSSMIC.2001.1008637
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2001-11-04
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Positron emission tomography Geometry Sensor arrays Crystals Anesthesia Animals Head Eyes Ear Laboratories
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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