NDLI: New polymer packaging for planar patch-clamp

Content Provider	IEEE Xplore Digital Library
Author	Sauter, F. d'Hahan, N.P. Pudda, C. Charles, R. Sordel, T. Garnier-Raveaud, S. Chatelain, F.
Copyright Year	2005
Description	Author affiliation: Dept. de la Recherche Technologique, Commissariat a l'Energie Atomique, Grenoble, France (Sauter, F.)
Abstract	We present a new microfluidic packaging dedicated to planar patch-clamp on silicon chip. The device allows the handling of living cells for typically 30 to 40 minutes including the steps of fluidic circulation, drug dispense and electrical measurement. This device is a tool for drug screening allowing parallel ion channel behaviour analysis. Combining microfabrication processes and a relevant microfluidic structure, we aim to increase the measurements throughput. In this paper, we focus on the technological choices required by the integration of the cells in a lab on chip. Materials have to be biocompatible and inert in a biological environment. Moreover, we show a novel modular assembly that allows the integration of electrodes on chips and eases the connexion of fluidic reservoirs. Our recent results demonstrate the efficiency of the system towards the gold standard patch-clamp technique. We recently recorded in whole-cell configuration the blockage by Iberiotoxin of BK channels stably expressed in HEK cells. This results show the ability of our system to provide the data needed by pharmaceutical industry to assess the efficiency or the toxicity of new drugs specifically targeting ion channels.
Starting Page	363
Ending Page	364
File Size	1399591
Page Count	2
File Format	PDF
ISBN	0780387112
DOI	10.1109/MMB.2005.1548475
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-05-12
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Polymers Packaging Drugs Microfluidics Semiconductor device measurement Silicon Electric variables measurement Throughput Pharmaceutical technology Biological materials patch-clamp cell on chips silicon packaging
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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