NDLI: Lab-on-a-chip devices for cell biology studies

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2006 International Conference on Microtechnologies in Medicine and Biology

2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology

2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology (IEEE Cat. No. 05EX937)

Program messages

Schedule/agenda

Schedule/agenda

Schedule/agenda

Conference committee

Keynote address

Table of contents

Nanoshuttles driven by biological motors

Opportunities for microtechnology in ion channel research

Insulating dielectrophoresis for the continuous separation and concentration of Bacillus subtilis

Multi-DNA extraction chip based on an aluminum oxide membrane integrated into a PDMS microfluidic structure

Continuous plasma separation from whole blood using microchannel geometry

Improving DNA microarray hybridization with a pulsed source-sink mixing device

Microfabricated fluorescence-activated cell sorter with hydrodynamic flow manipulation

Dual capillary electrophoresis devices with electrochemical detection on a single platform

Lab-on-a-chip systems with three dimensional microelectrodes

Open environment micro device for integration of patch clamp instrumentation with targeted microfluidic chemical delivery

Influence of oxygen microenvironment on microfluidic glucose sensor performance

Automated multiplexed multidensity microfluidic (M/sup 3/) cell sensing based on electrical gain measurements

A PDMS microfluidic spotter for fabrication of lipid microarrays

A microfluidic assembly line for adherent cell assays

Microfluidic blood/plasma separation unit based on microchannel bend structures

High throughput microfluidic system for heterogeneous assays

MEMS ultrasonic ejector array for electrospray mass spectrometry of biomolecules

Flat-chip microanalytical enzyme sensor for salivary amylase activity

Electrophoretic immunoassays for oral diagnostics

Development of miniaturized in situ analysis devices for biological and chemical oceanography

MEMS-based biochip for the characterization of single red blood cell

High-throughput microfluidic devices for NO assay based on electrophoretic separation

Detection of a cardiac infarct on a disposable lab on a chip device

Optical measurements on drain fluid for the detection of anastomotic leakage

A MEMS RF-interrogated biosensor

Traveling wave bio-agent concentrator

Movable microprobes for the brain

Tactile display for 2-D and 3-D shape expression using SMA micro actuators

A miniaturized low power personal motion analysis logger utilizing MEMS accelerometers and low power microcontroller

Implantable CMOS-based stimulator/reader design for retinal prosthesis

A retinal neuroprosthesis design based on simultaneous current injection

Tissue micromotion induced stress around brain implants

Power efficient multiple voltage stimulation for implantable retinal prosthesis

Augmenting real-time DSP in implantable high-density neuroprosthetic devices

A three-dimensional microassembly structure for micromachined planar microelectrode arrays

Implantable parylene MEMS for glaucoma therapy

Computer simulation of eddy current loss reduction for rechargeable cardiac pacemaker

Investigation of multi-sensor techniques for cardiac-output measurements in intensive care

Low-pressure treatment control of glaucoma using an electromagnetic valve actuator with a piezoresistive pressure sensor

Development of a small wireless position and bleeding detection sensor

Implantable, transcutaneously powered neurostimulator system to restore gastrointestinal motility

Design optimization of integer lifting DWT circuitry for implantable neuroprosthetics

Application of a novel widefield surface plasmon microscope in binding assays

Fabrication and test of a submicroliter-level thermopneumatic micropump for transdermal drug delivery

A low power, polyimide valved micropump for precision drug delivery

Fabrication of multilayered particles with structured, complex three-dimensional architecture

Ligand-conjugated quantum dots for targeted drug delivery to nerve cells

Focused ultrasonic device for sonodynamic therapy in the human body

Spatially controlled sonoporation of prostate cancer cells via ultrasound activated microbubble cavitation

Ultra high speed observations of cavitation derived microjetting phenomena

Protein encapsulated magnetic carriers for micro/nanoscale drug delivery systems

Piezoelectric 2D microscanner for precise laser treatment in the human body

125 /spl mu/m diameter fiber-optic pressure sensor system using spectrometer-based white light interferometry with high-speed wavelength tracking

Biological insight into future technology - what living cells tell us

Lab-on-a-chip devices for cell biology studies

Pattern formation of adhesive beads to channels in microfluidic devices for cell culture

Indium tin oxide electrodes for cell-based biosensors

Co-culture of cells in PDMS microsystem for sensitized artificial skin

Cellular responses to nanotopology of polymeric surfaces fabricated with AAO nanoimprinting

Control of human skin cell adhesion, proliferation and migration by microengineered substrata: transposition from solid phase to clinically relevant materials

Surface engineering of microfluidic systems for cellular biochips

Cytoskeletal networks in an epithelial sheet: mechanical characterization using composite diaphragm inflation

Monitoring capillary endothelial cell culture and capillary formation in a microdevice by impedance spectroscopy measurements

Electrophoretic control of actomyosin motility

Planar off-chip microelectrode for the electrophysiological measurement of small biological cells

Evaluation of micromotion of vascular endothelial cells with estrogen in electrical cell-substrate impedance sensing (ECIS) method using a mathematical model cell-to-cell distance and cell-to-substrate distance

Tripodal thiol-derivatives as a functional interface monolayer for immobilization of biomolecules

Direct detection of single-base extension reaction using genetic field effect transistor

Micro-nanotechnologies for heart failure: improving quality of life

Ultra small reaction chamber array for single-molecule studies of biological reaction

A single-cell electroporation device with integrated perfusion channels for efficient intracellular delivery

Miniaturized ECL detection system for glucose biosensor

Three-dimensionally patterned cardiomyocytes with high activity for powering bio-hybrid microdevices

Fabrication of nanosize patterned substrates using nano imprinting lithography

A scale-up prototype of PZT thin-film actuators for scanning endoscopes

Small diameter hydraulic active bending catheter using laser processed super elastic alloy and silicone rubber tube

Active bending ileus tube using shape memory alloy for treatment of intestinal obstruction

Fundamental design rules for the conception of microdevices to be propelled in the blood circulatory system through magnetic gradients generated by a clinical MRI system

Nanofluidic interconnects within a multilayer microfluidic chip for attomolar biochemical analysis and molecular manipulation

Control techniques of kinesin-driven beads in microfluidic devices

Microfluidic packaging of suspended microchannel resonators for biomolecular detection

A dynamic vapor control system for nanovolume chemistry and protein crystallization

Formation process of planar lipid bilayer observed by confocal microscopy

A magnetohydrodynamic (MHD) microfluidic platform for cell switching

Particle mixing and concentration through competing electrokinetic and hydrodynamic flows

Quantifying viscoelastic behavior of DNA-laden flows in microfluidic systems

Magnetizable intravascular stents for sequestration of systemically circulating magnetic nano- and microspheres

A microfluidic model of microbubble lodging in small arteriole bifurcations

Effects of surface roughness on the flow characteristics in PDMS microchannels

Progress in R&D on wearable and implantable biomedical sensors for better healthcare and medicine

The integration of bio, micro and nano technologies to produce a range of medical implants from the Healthy Aims project

Mechanically robust micro-fabricated strain gauges for use on bones

Lithography combined with multilayer nanoassembly: versatile approach to fabricate nanocomposite micropatterns for biointerfaces

Micromachined tacks for retinal implant applications

Characterization of micromanipulator controlled dry spinning of micro- and nanoscale polymer fibers

Aligning system for the in-situ microfabrication of multiple microstructures

MRI velocimetry in microchannel networks

Novel technological process to manufacture ceramic microelectrodes for biomedical applications implying microextrusion of preceramic precursors

Design and fabrication of a multianalyte-capable optical biosensor using a multiphysics approach

Effects of alginate, hyaluronic acid and high voltage electrostatic field on the fibrillogenesis of collagen II

Direct immobilization and patterning of hyaluronic acid on hydrophilic substrates

Integrated photonic crystal waveguides for micro-bioanalytical devices

Wireless wearable biomonitors for lifetime wellness optimization

Intrinsic optical signal imaging of a ratiometric fluorescence oxygen nanosensor

Development of a platform for microscale monitoring of cell function and differentiation

Forward-looking ultrasound imager using convex-shaped 1-3composite transducer for intravascular treatment

Improved and simple sealing of microfluidic structures

Modeling and simulation of DNA flow in a microfluidic-based pathogen detection system

Particle simulation of traveling wave gel electrophoresis

Microanalytical technologies to monitor cellular signaling

Screening cellular responses to cytokine pulses in a microfluidic device

New polymer packaging for planar patch-clamp

Micro-3D cell culture devices for single cell analysis

Raised lateral patch clamp array

Electrophysiological biosensor with micro channel array for multipoint measurement of signals from distributed cells

Self-aligned bio probe with novel operating mechanism for extra and intra cellular measurement

A microfluidic coculture system for cell-cell interaction study

Microfluidic cell culture array for on-chip cell biology

Investigation of human hepatoma cell line in microfluidic devices

Single red blood cell deformability test using optical trapping in plastic microfluidic chip

Negotiation of obstacles by fungi in micro-fabricated structures: to turn or not to turn?

Reconfigurable protein matrices for prolonged neuroblasts patterning and retraction

Electrochemical bio-lithography for in situ control of cellular adhesion and growth on a chip

Investigation of temperature gradient effects on neurite outgrowth in nerve cells using a microfabricated heater structure

Measurement of mechanical properties of Caenorhabditis elegans with a piezoresistive microcantilever system

Insect muscle potential recording by an epoxy-based multichannel microelectrode

MEMS platform for studying neurogenesis under controlled mechanical tension

2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.02EX578)

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)

Lab-on-a-chip devices for cell biology studies

Content Provider	IEEE Xplore Digital Library
Author	Folch, A.
Copyright Year	2005
Description	Author affiliation: Washington Univ., St. Louis, MO, USA (Folch, A.)
Abstract	Microtechnology offers the attractive possibility of modulating the microenvironment of single cells and, for the same price, obtain data at high throughput for a small cost. Microfluidic or "Lab on a Chip" devices, in particular, promise to play a key role for several reasons: 1) the dimensions of microchannels can be comparable to or smaller than a single cell; 2) the unique physicochemical behavior of liquids confined to microenvironments enables new strategies for delivering compounds to cells on a subcellular level; 3) the devices consume small quantities of precious/hazardous reagents (thus reducing cost of operation/disposal); and 4) the can be mass-produced in low-cost, portable units. Not surprisingly, in recent years there has been an eruption of microfluidic implementations of a variety of traditional bioanalysis techniques. I will review the latest efforts of our laboratory in the development of cell-based microdevices for cell biology studies, such as neuromuscular synaptogenesis, axon guidance, and chemotaxis.
File Size	129365
File Format	PDF
ISBN	0780387112
DOI	10.1109/MMB.2005.1548418
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-05-12
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Lab-on-a-chip Biological cells Costs Microfluidics Throughput Microchannel Liquids Laboratories Neuromuscular Nerve fibers
Content Type	Text
Resource Type	Article

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