NDLI: Microfluidic packaging of suspended microchannel resonators for biomolecular detection

Content Provider	IEEE Xplore Digital Library
Author	Burg, T.P. Manalis, S.R.
Copyright Year	2005
Description	Author affiliation: Dept. of Electr. Eng. & Comput. Sci., Massachusetts Univ., USA (Burg, T.P.)
Abstract	Microfabricated transducers enable the label-free detection of biomolecules in nanoliter size samples. We have recently developed a new resonant micromechanical mass sensor that is exceptionally well suited for the detection of biomolecular interactions in a microfluidic framework. Our approach completely eliminates viscous damping by confining the fluid to the inside of a hollow resonator of less than 0.1 nL volume. However, previously we had not been able to integrate all device components and the connecting fluidics in a single package. In this paper, we present for the first time a complete chip-level package that enables efficient fluid delivery and, at the same time, provides integrated electrical contacts to actuate the resonator electrostatically. Combining these components required the development of a new packaging process: thin gaskets of poly(dimethylsiloxane) (PDMS) are micromolded and then bonded in selected areas to a metallized and patterned carrier substrate. While the process flow was specifically developed for the resonant sensor described below, the result is a general technique that can greatly simplify the packaging of many other biomedical devices using microfluidics.
Starting Page	264
Ending Page	267
File Size	3003813
Page Count	4
File Format	PDF
ISBN	0780387112
DOI	10.1109/MMB.2005.1548444
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-05-12
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microfluidics Packaging Microchannel Resonance Biosensors Transducers Molecular biophysics Micromechanical devices Damping Joining processes low-temperature bonding label-free biosensor resonant mass sensor vibrating tube resonator PDMS
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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