NDLI: Electrochemical bio-lithography for in situ control of cellular adhesion and growth on a chip

Content Provider	IEEE Xplore Digital Library
Author	Nishizawa, M. Kaji, H.
Copyright Year	2005
Description	Author affiliation: Dept. of Bioeng. & Robotics, Tohoku Univ., Sendai, Japan (Nishizawa, M.; Kaji, H.)
Abstract	Controlling the interfaces between cells and materials is important subject for a wide range of research fields such as cell biology, tissue engineering, and biomedical devices. Here we report a novel electrochemical method to direct the adhesion and growth of mammalian cells on a substrate during cultivation in situ, named "Electrochemical Bio-Lithography". We found that the cell-repellent nature of the albumin- or heparin-coated substrates can be locally switched to cell-adhesive, by treatment with hypobromous acid electrochemically generated at the tip of the scanning microelectrode. Since this technique can be conducted under typical physiological conditions, we were able to direct cellular proliferation and migration by drawing adhesive micropatterns over the preexisting cellular pattern. The integration of this electrochemical system into a microfluidic device will provide a novel type of cell-chip, which enables on-demand immobilization of cells just prior to the use of devices.
Starting Page	396
Ending Page	397
File Size	1715847
Page Count	2
File Format	PDF
ISBN	0780387112
DOI	10.1109/MMB.2005.1548486
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-05-12
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Adhesives Microelectrodes Cells (biology) Microfluidics Glass Electrodes Biomedical engineering Biological materials Soft lithography Surface treatment Microelectrode Patterning Cells
Content Type	Text
Resource Type	Article

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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