NDLI: Detection of Alzheimer's disease through automated hippocampal segmentation

Content Provider	IEEE Xplore Digital Library
Author	Rangini, M. Jiji, G.W.
Copyright Year	2013
Description	Author affiliation: Comput. Sci. & Eng., Dr. Sivanthi Aditanar Coll. of Eng., Tiruchendur, India (Rangini, M.; Jiji, G.W.)
Abstract	We trained our approaches using T1-weighted brain MRIs from 30 subjects [10 normal elderly, 10 mild cognitive impairment (MCI), and 10 Alzheimer's disease (AD)], and tested on an independent set of 40 subjects (20 normal, 20 AD). Here we registered all of the brain images into the same stereotaxic space. Then we define a bounding box around the training hippocampal plus some neighborhood voxels). We compared two automated methods for hippocampal segmentation using different machine learning algorithms: 1) support vector machines (SVM) with manual feature selection, 2) hierarchical SVM with automated feature selection (Ada-SVM). After surface reconstruction, we computed significance maps, and overall corrected p-values, for the 3-D profile of shape differences between AD and normal subjects. We assessed each approach's accuracy relative to manual segmentations, and its power to map AD effects. Our AdaBoost and Ada-SVM segmentations compared favorably with the manual segmentations. We also evaluated how segmentation accuracy depended on the size of the training set, providing practical information for future users of this technique.
Sponsorship	IEEE Kerala Sect.
Starting Page	144
Ending Page	149
File Size	691319
Page Count	6
File Format	PDF
ISBN	9781467350891
e-ISBN	9781467350907
DOI	10.1109/iMac4s.2013.6526397
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-03-22
Publisher Place	India
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Support vector machines Training Image segmentation Magnetic resonance imaging AdaSVM Hippocampal segmentation Support vector machines (SVMs) Alzheimer's disease Hippocampus
Content Type	Text
Resource Type	Article

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