NDLI: Reentrant activity in a virtual 3D ventricular slab preparation subject to regional simulated ischemia: Role of the ischemic zone size

Content Provider	IEEE Xplore Digital Library
Author	Romero, L. Heidenreich, E. Rodriguez, J.F. Trenor, B. Ferrero, J.M. Saiz, J. Doblare, M.
Copyright Year	2008
Description	Author affiliation: Univ. Politec. de Valencia, Valencia (Romero, L.; Trenor, B.; Ferrero, J.M.; Saiz, J.) \|\| Univ. de Zaragoza, Zaragoza (Heidenreich, E.; Rodriguez, J.F.; Doblare, M.)
Abstract	Many aspects about generation of reentrant arrhythmias during regionally acute ischemia remain unclear. The goal of the present work is to study the effects of the size of the central ischemic zone (CZ) in a realistic 3D tissue by means of computer simulations.Simulations were run using a modified version of the Luo-Rudy dynamic action potential model (LRd00) and accounting for fiber orientation in the slab preparation. Our results show that, for a non centered ischemic zone of 25 mm in diameter, premature stimuli applied at coupling intervals comprised between 167 ms and 190 ms lead to reentry. Therefore, the width of the vulnerable window (VW) for re-entry yields 24 ms while for 20 mm in diameter, the VW shrank to 19 ms. In addition, for bigger CZ diameter, figure-of-eight reentries are initiated closer to the epicardium. In conclusion, in a 3D regionally ventricular slab, a bigger size of the ischemic zone widens the VW for reentry.
Starting Page	1025
Ending Page	1028
File Size	371101
Page Count	4
File Format	PDF
ISBN	9781424437061
ISSN	02766547
DOI	10.1109/CIC.2008.4749219
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-09-14
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Computers in Cardiology(CinC)
Subject Keyword	Slabs Ischemic pain Computational modeling Computer simulation Equations Fibrillation Heart ventricles Myocardium Morphology Arteries
Content Type	Text
Resource Type	Article

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