NDLI: Adaptive modeling of ionic membrane currents improves models of cardiac electromechanics

Content Provider	IEEE Xplore Digital Library
Author	Kuijpers, N.H.L. ten Eikelder, H.M.M. Prinzen, F.W.
Copyright Year	2008
Description	Author affiliation: Eindhoven Univ. of Technol., Eindhoven (ten Eikelder, H.M.M.) \|\| Maastricht Univ., Maastricht (Kuijpers, N.H.L.; Prinzen, F.W.)
Abstract	A change in activation sequence by means of pacing induces changes in action potential (AP) morphology and duration. These changes are caused by electrical remodeling of ionic membrane currents and are reflected in the T wave in the electrocardiogram (ECG). Also the calcium transient is affected, which leads to changes in cardiomechanics. By modeling the cardiac muscle as a single fiber, we investigated whether electrical remodeling may be triggered by changes in mechanical load. A homogeneous distribution of electrophysiology in our model resulted in an inhomogeneous distribution of stroke work. After remodeling of the ionic membrane currents, contraction was more homogeneous and the repolarization wave was reversed. These results are in agreement with experimentally observed homogeneity in mechanics and heterogeneity in electrophysiology. In conclusion, adaptive modeling of electrophysiology may improve current models of cardiac electromechanics.
Starting Page	429
Ending Page	432
File Size	319767
Page Count	4
File Format	PDF
ISBN	9781424437061
ISSN	02766547
DOI	10.1109/CIC.2008.4749070
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-09-14
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Computers in Cardiology(CinC)
Subject Keyword	Biomembranes Muscles Heart Hidden Markov models Calcium Morphology Electrocardiography Cardiology Extracellular Boundary conditions
Content Type	Text
Resource Type	Article

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