NDLI: Effect of lidocaine in acute ischemic situations: A computer modelling study

Content Provider	IEEE Xplore Digital Library
Author	Cardona, K. Saiz, J. Ferrero, J.M. Martinez, M. Molto, G. Hernandez, V.
Copyright Year	2008
Description	Author affiliation: High Performance Networking & Comput. Group, UPV, Valencia (Molto, G.; Hernandez, V.) \|\| Grupo Predictive Control & Heuristic Optimization Res. Group, UPV, Valencia (Martinez, M.) \|\| Center for Res. & Innovation on Bioingineering, UPV, Valencia (Cardona, K.; Saiz, J.; Ferrero, J.M.)
Abstract	Lidocaine is a drug that blocks the sodium channel in a pH, frequency and concentration dependent manner. In this work, we have used a mathematical model of lidocaine developed by our group and incorporated it into the Luo Rudy model of ventricular action potential. We have studied the action of lidocaine on the sodium current $(I_{Na}),$ maximum upstroke velocity (dV/dt) and conduction velocity (CV) in ischemic tissue. Additionally, we measured the block window (BW) in different concentrations of drug .Our results show that 100 mumol/L of lidocaine under simulated acute ischemic conditions reduces the $I_{Na},$ dV/dt and CV a 42%, 41% and 24% in the normal zone (cell 54), respectively while in the border zone (cell 94) the decreased was 37%; 44% and 18% for the same parameters. Finally, we have found that lidocaine diminished the BW, thus the drug tends to eliminate the UDB.
Starting Page	1017
Ending Page	1020
File Size	244962
Page Count	4
File Format	PDF
ISBN	9781424437061
ISSN	02766547
DOI	10.1109/CIC.2008.4749217
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-09-14
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Computers in Cardiology(CinC)
Subject Keyword	Drugs Myocardium Ischemic pain Mathematical model Computer networks High performance computing Kinetic theory Extracellular Computational modeling Predictive models
Content Type	Text
Resource Type	Article

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