NDLI: The photopic negative response of the flash ERG: changes in experimental glaucoma in monkeys and clinical applications in humans

Content Provider	IEEE Xplore Digital Library
Author	Frishman, L.J. Viswanathan, S. Robson, J.G.
Copyright Year	2002
Description	Author affiliation: Coll. of Optometry, Houston Univ., TX, USA (Frishman, L.J.)
Abstract	The flash electroretinogram (ERG), which can be recorded noninvasively at the cornea, has commonly been used to assess photoreceptor and bipolar cell activity, reflected in the initial negative (a-wave) and positive (b-) waves respectively of the response to a brief flash. In this study we measured light-adapted (photopic) flash ERGs using red flashes on a rod saturating blue background, and discovered a negative-going wave after the b-wave which we called the photopic negative response (PhNR). Pharmacological studies in monkeys indicated that the PhNR arises from the spiking activity of inner retinal neurons proximal to bipolar cells, predominantly retinal ganglion cells. We measured the PhNR in monkeys with experimental glaucoma and human patients with primary open angle glaucoma (POAG), pathologies that eventually destroy ganglion cells. PhNR amplitudes were already significantly reduced (P<0.5) relative to controls in monkey eyes with experimental glaucoma and in POAG patients when visual sensitivity losses, assessed using perimetry, were mild (mean deviation of less than -6dB). PhNR amplitudes also were reduced in glaucoma suspects. These findings suggest promise for the PhNR for early detection of glaucomatous damage.
Starting Page	2131
Ending Page	2132
File Size	240981
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1053203
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Humans Retina Cornea Diseases Neurons Pathology Educational institutions Photoreceptors Eyes Photoconductivity
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Blue-on-Green Flash Induces Maximal Photopic Negative Response and Oscillatory Potential and Serves as a Diagnostic Marker for Glaucoma in Rat Retina.

The photopic negative response (PhNR): measurement approaches and utility in glaucoma.

The photopic negative response of flash ERG in nonproliferative diabetic retinopathy

The photopic negative response of the flash electroretinogram in primary open angle glaucoma.

Clinical study comparison of photopic negative response of full-field and focal electroretinograms in detecting glaucomatous eyes.

Page1, tanimoto et al. Negative scotopic erg and photopic erg on response impairment in a patient with normal dark adaptation subtitle: negative erg with normal dark adaptation.

Short-Term Changes in the Photopic Negative Response Following Intraocular Pressure Lowering in Glaucoma.

Optimizing a Portable ERG Device for Glaucoma Clinic: The Effect of Interstimulus Frequency on the Photopic Negative Response

Photopic negative response in diagnosis of glaucoma:an experimental study in glaucomatous rabbit model

The photopic negative response of the flash ERG: changes in experimental glaucoma in monkeys and clinical applications in humans

Similar Documents

Blue-on-Green Flash Induces Maximal Photopic Negative Response and Oscillatory Potential and Serves as a Diagnostic Marker for Glaucoma in Rat Retina.

The photopic negative response (PhNR): measurement approaches and utility in glaucoma.

The photopic negative response of flash ERG in nonproliferative diabetic retinopathy

The photopic negative response of the flash electroretinogram in primary open angle glaucoma.

Clinical study comparison of photopic negative response of full-field and focal electroretinograms in detecting glaucomatous eyes.

Page1, tanimoto et al. Negative scotopic erg and photopic erg on response impairment in a patient with normal dark adaptation subtitle: negative erg with normal dark adaptation.

Short-Term Changes in the Photopic Negative Response Following Intraocular Pressure Lowering in Glaucoma.

Optimizing a Portable ERG Device for Glaucoma Clinic: The Effect of Interstimulus Frequency on the Photopic Negative Response

Photopic negative response in diagnosis of glaucoma:an experimental study in glaucomatous rabbit model

The photopic negative response of the flash ERG: changes in experimental glaucoma in monkeys and clinical applications in humans