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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Baig-Silva, M.S. Hetling, J.R. |
| Copyright Year | 2002 |
| Description | Author affiliation: Bioeng. Dept., Illinois Univ., Chicago, IL, USA (Baig-Silva, M.S.; Hetling, J.R.) |
| Abstract | The homozygous parent strain of the P23H transgenic rat (developed as an animal model or retinal degeneration associated with human eye disease) was crossed with pigmented wild-type (Long Evans) rats. The pigmented offspring, heterozygous for the mutation in the rhodopsin gene, more closely resemble the human disease state. Single and paired-flash electroretinography was used to evaluate the retinal response to brief light flashes. A-wave amplitudes and sensitivity decreased with age up to 12 wks (the oldest rats currently in the colony); b-wave amplitudes and sensitivity were relatively preserved up to 12 wks. At 4 wks of age, the transgenic rats showed an earlier time to peak of the paired-flash-derived photoreceptor response, and a faster initial recovery from peak, when compared to age-matched wild-type. |
| Starting Page | 1992 |
| Ending Page | 1993 |
| File Size | 202439 |
| Page Count | 2 |
| File Format | |
| ISBN | 0780376129 |
| ISSN | 1094687X |
| DOI | 10.1109/IEMBS.2002.1053132 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2002-10-23 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Pigmentation Rats Animals Retina Humans Degenerative diseases Testing Capacitive sensors Genetic mutations Photoreceptors |
| Content Type | Text |
| Resource Type | Article |
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