NDLI: RF ablation at audio frequencies preferentially targets tumor

Content Provider	IEEE Xplore Digital Library
Author	Haemmerich, D. Mahvi, D.M. Lee Jr., F.T. Webster, J.G.
Copyright Year	2002
Description	Author affiliation: Dep. of Surg., Univ. of Wisconsin-Madison, Stoughton, WI, USA (Haemmerich, D.; Mahvi, D.M.)
Abstract	Radio Frequency (RF) ablation has become of considerable interest as a minimally invasive treatment for primary and metastatic liver tumors. Major limitations are small lesion size, which make multiple applications necessary and incomplete killing of tumor cells, resulting in high recurrence rates. RF ablation is typically carried out in the frequency range of around 500 kHz. Measurements have shown a marked difference in electrical conductivity between normal liver tissue and tumor tissue. The difference is most pronounced at frequencies below 100 kHz, where tumors exhibit around two times higher conductivity compared to normal tissue. Conductivity is similar for tumor and normal liver at 500 kHz. We created Finite Element Method (FEM) models of the RITA model-30 multi-prong probe. The probe was placed in a tumor of 20 mm diameter. We simulated 12 minute, temperature controlled RF ablation at 95/spl deg/C at frequencies of 20 kHz and 500 kHz. At 20 kHz we observed increased current density within the tumor boundaries. This resulted in an increase in lesion size by 29% at a frequency of 20 kHz compared to 500 kHz.
Starting Page	1797
Ending Page	1798
File Size	224034
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1053030
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Radio frequency Finite element methods Liver neoplasms Lesions Probes Minimally invasive surgery Metastasis Tumors Conductivity measurement Electric variables measurement
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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