NDLI: A self-assembly conductive device for direct DNA identification in integrated microarray based system

Content Provider	IEEE Xplore Digital Library
Author	Mei Xue Jiong Li Wen Xu Zuhong Lu Wang, K.L. Ko, P.K. Mansun Chan
Copyright Year	2002
Description	Author affiliation: Dept. of Electr. & Electron. Eng., Hong Kong Univ. of Sci. & Technol., Kowloon, China (Mei Xue)
Abstract	A self-assembly conductive method for DNA identification has been demonstrated to be used in an array based microelectronic biochip. The detailed fabrication steps of the device and the procedures to identify targeted samples with gold nanoparticle labels are presented. By using the pre-hybridization and amplification method, the sensitivity of this array-based microelectronic biochip exceeds that of a traditional fluorescence detection system by three orders of magnitude. The device is simple and compatible with standard IC fabrication technology with slight modification to the last passivation and metallization process. A substantial difference in current is measured from the device with matched and unmatched DNA samples, which can be easily detected by any modern IC comparator.
Sponsorship	Electron. Devices Soc. IEEE
Starting Page	207
Ending Page	210
File Size	371105
Page Count	4
File Format	PDF
ISBN	0780374622
DOI	10.1109/IEDM.2002.1175814
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-12-08
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Self-assembly DNA Microelectronics Fabrication Gold Nanoscale devices Fluorescence Passivation Metallization Current measurement
Content Type	Text
Resource Type	Article

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