NDLI: Repressilators and promotilators: loop dynamics in synthetic gene networks

Content Provider	IEEE Xplore Digital Library
Author	El Samad, H. Del Vecchio, D. Khammash, M.
Copyright Year	2005
Description	Author affiliation: Dept. of Mech. Eng., California Univ., Santa Barbara, CA, USA (El Samad, H.)
Abstract	Oscillators and switches are ubiquitous in gene regulatory networks. Understanding the dynamical properties of these systems is a necessity not only to reverse engineer their structure, but also to forward engineer novel structures in the context of the nascent field of "synthetic biology". In this work, we analyze two classes of cyclic gene networks. The first class corresponds to the "repressilator", which is to polemically equivalent to a class of negative gain networks. The second class corresponds to the "promotilator" which is topologically equivalent to a class of positive gain networks. We demonstrate that the repressilator can exhibit oscillatory behavior under conditions that we derive. We also demonstrate that the promotilator and its equivalent circuits belong to the class of strongly monotone systems, and as such, the behavior they can exhibit is convergence to stable equilibria.
Sponsorship	American Automatic Control Council
Starting Page	4405
Ending Page	4410
File Size	246358
Page Count	6
File Format	PDF
ISBN	0780390989
ISSN	07431619
e-ISBN	0780390997
DOI	10.1109/ACC.2005.1470689
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-06-08
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	American Automatic Control Council(AACC)
Subject Keyword	Intelligent networks Oscillators Proteins Control systems Switches Synchronization Reverse engineering Equivalent circuits Genetics Buildings
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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