NDLI: Development of a Disposable Bio-Microfluidic Package With Reagents Self-Contained Reservoirs and Micro-Valves for a DNA Lab-on-a-Chip (LOC) Application

Content Provider	IEEE Xplore Digital Library
Author	Ling Xie Premachandran, C.S. Chew, M. Ser Choong Chong
Copyright Year	1999
Abstract	A disposable self-contained microfluidic package has been developed and tested for on-chip DNA extraction from human blood for practical lab-on-a-chip platform. The microfluidic package has been customized to allow easy interface between the microscale sample injection to the Si-based microscale sample preparation chip. For precise sample dispensing and to minimize dead volume and/or sample lost conical-shaped reservoirs have been employed. Reservoirs filled with reagents are sealed by a highly elastic thin rubber membrane. Automated actuation system has been designed and implemented for programmable sample/reagent dispensing using thin rubber membrane-plunger mechanism. The packaged DNA chip has been tested using blood sample and the testing protocol has been optimized to meet the requirements for DNA extraction.
Sponsorship	IEEE Components, Packaging, and Manufacturing Technology Society IEEE Components, Packaging and Manufacturing Technology Society
Starting Page	528
Ending Page	535
Page Count	8
File Size	2311391
File Format	PDF
ISSN	15213323
Volume Number	32
Issue Number	2
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-05-01
Publisher Place	U.S.A.
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Lab-on-a-chip Packaging Reservoirs Microvalves DNA Microfluidics Blood Rubber Automatic testing Humans self-contained reagent Disposable package lab-on-a-chip (LOC) microfluidic dispense microfluidic package
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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